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Curcumin regulates inflammation and apoptosis through PARP-1 and NF-κB in ethanol-induced gastric ulcer model

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Title Curcumin regulates inflammation and apoptosis through PARP-1 and NF-κB in ethanol-induced gastric ulcer model
 
Creator Mete, Keçeci
Meryem, Akpolat Ferah
Habib, Khoshvaghti
Serkan, Karaçetin
 
Subject Antiapoptotic
Anti-inflammatory
Curcuma longa
Caspases
Inflammatory cytokines
Turmeric
 
Description 83-92
Curcumin is a natural polyphenol with antioxidant, antiapoptotic and anti-inflammatory properties. In the present study,
we explored the roles of PARP-1 and NF-κB molecules in the inflammation and apoptosis modulation caused by curcumin
in the ethanol-induced gastric ulcer model. Male wistar albino rats (n=32) were divided into four groups. A single dose of
1 mL corn oil was given orally to the normal control and ethanol groups. After 30 minutes of after corn oil application, 1 mL
of absolute alcohol was administered orally to the ethanol group. The curcumin group was given 100 mg/kg curcumin
orally. In the ethanol+curcumin group, 1 mL of absolute alcohol was given orally 30 min after 100 mg/kg oral curcumin
administration. The study evaluated the macroscopic and microscopic ulcer scores, as well as mucosal barrier integrity,
using hematoxylin-eosin and PAS staining. Apoptotic and inflammatory pathways were examined by immunohistochemical
staining, and malodialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were examined in
tissue. Compared with the ethanol group, macroscopic and microscopic mucosal lesions, MPO and MDA levels, and IL-1,
IL-6, TNF-α, PARP-1, NFκB and Caspase-3, 8, 9 expressions were seen to decrease in the ethanol+curcumin group,
however SOD level was observed to increase. The study demonstrated that curcumin protects the mucosal integrity by
exhibiting anti-inflammatory andantiapoptotic effects through the modulation of PARP-1 and NF-κB key molecules in the
ethanol-induced gastric ulcer model.
 
Date 2024-01-31T11:28:42Z
2024-01-31T11:28:42Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63279
https://doi.org/10.56042/ijeb.v62i02.3848
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]