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A 28KDa recombinant outer membrane protein of Brucella melitensis downregulates type-1 immune response in mice

Indian Agricultural Research Journals

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Title A 28KDa recombinant outer membrane protein of Brucella melitensis downregulates type-1 immune response in mice
 
Creator Kaushik, P
Singh, D K
Tiwari, A K
Dayal, S
Shukla, G
Quasim, A
Singha, H
Kumar, B
Chaudhury, P
 
Subject Brucella
Omp28
Type-1 immune response
 
Description A 28 kDa recombinant outer membrane protein (r-omp28) of Brucella melitensis was evaluated for the induction of immune response in mice. The study demonstrated the downregulation of type-1 immune response in mice vaccinated with r-omp28 of B. melitensis. The level of IgG2a was observed significantly lower than IgG1 in mice immunized with r-omp28. The cytokine profile and proliferation of cells was characteristic of Th2 type as we detected significantly high level of IL-10 but no or significantly low level of IL-2 and IFN-g. Further, the production of gamma-interferon (IFN-g) was downregulated by r-omp28. Therefore, it implies that B. melitensis r-omp28 might down-regulates type-1 immune response in vaccinated mice.
 
Publisher Indian Council of Agricultural Research
 
Date 2012-09-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/23655
10.56093/ijans.v82i9.23655
 
Source The Indian Journal of Animal Sciences; Vol. 82 No. 9 (2012); 1006–1008
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/23655/11339
 
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https://creativecommons.org/licenses/by-nc-sa/4.0