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Preparation and evaluation of spray dried powder of Trigonella foenum-graecum seeds as suspending agents to develop rivaroxaban nanosuspension

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Title Preparation and evaluation of spray dried powder of Trigonella foenum-graecum seeds as suspending agents to develop rivaroxaban nanosuspension
 
Creator Nadendla, Rama Rao
Rao, KRS Sambasiva
Kanna, Sandeep
Satyanarayana, Juluri
Mrudhvani, Charugulla
 
Subject Minitab
Mucilage
Rivaroxaban
Zeta potential
 
Description 105-117
The present study aimed to formulate rivaroxaban nanosuspension by nanoprecipitation with the ultrasonication method
and was stabilized by different concentrations of Fenugreek Seed Mucilage, Microcrystalline Cellulose and Carboxymethyl
Cellulose. The formulated nanosuspensions were evaluated for saturation solubility studies, particle size, drug content, zeta
potential, and in vitro drug release. In the FT-IR spectra of the drug in the physical mixture, it was noted that the peaks had
remained unaltered. DSC thermograms of Rivaroxaban and the physical mixture indicated the absence of interaction and the
presence of the drug in an unchanged form. The evaluation tests were conducted and optimization was done using Minitab
software. Optimized formulation F3 demonstrated an impressive saturation solubility of 0.89 mg/mL. The particle size
distribution studies revealed that the optimized formulation F3 showed 79 nm. Formulation F3 exhibited drug content
reaching 75%. The zeta potential was measured at -33 mV for formulation F3. Pure drug RN exhibited a cumulative drug
release of 20%, and formulation F3 showed 71% cumulative drug release at the end of the 60th min. Rivaroxaban
nanosuspension showed a prolonged duration of drug action, enhanced the rate and extent of drug absorption, and ultimately
increased the therapy's effectiveness.
 
Date 2024-01-30T11:39:29Z
2024-01-30T11:39:29Z
2024-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63266
https://doi.org/10.56042/ijbb.v61i2.6922
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(02) [February 2024]