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Evaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs)

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Title Evaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs)
 
Creator Akay, Feryal
Toptancı, Bircan Çeken
İnceören, Nesrin
Kızıl, Göksel
Kızıl, Murat
 
Subject DNA fructosylation
DNA oxidation
DNA-AGEs
Morus nigra L
Reactive oxygen species
 
Description 75-84
In the developing countries there is a direct correlation between the amount of consumed foods containing starch and the
increase in metabolic diseases. In contrast to glucose, fructose cannot be detected in the blood by insulin. Thus, it participates in
lipogenesis and increases intracellular lipid accumulation.Reducing sugars results in the development of AGEs (Advanced
Glycation End-Compounds) in biological macromolecules as well as some reactive products. These products can cause tissue
damage by accumulating in the pathogenesis of a number of diseases by various mechanisms.AGEs can damage antioxidant
systems by increasing ROS (reactive oxygen species). In this study, pBR322 DNA was incubated with different concentrations
of fructose for 5 days. Damage to the structural system of fructosylated DNA was detected by an increase in fluorescence
intensity and hyperchromicity. For five days, fructosylated DNA was treated with varying quantities of Morus nigra L. soxhlet
extract and quercetin, and its impact on DNA structural damage was noted. The reduction in hyperchromicity and fluorescence
intensity revealed the protective impact of quercetin and M. nigra L. extract on DNA. It has been found that the extract of
M. nigra L. and quercetin both scavenge free radicals and reduce fructose-induced DNA damage.
 
Date 2024-02-06T07:41:19Z
2024-02-06T07:41:19Z
2024-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63310
https://doi.org/10.56042/ijbb.v61i2.1610
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(02) [February 2024]