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Therapeutic effects of chewable fluralaner against Sarcoptes scabiei infestations in dogs

Indian Agricultural Research Journals

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Title Therapeutic effects of chewable fluralaner against Sarcoptes scabiei infestations in dogs
 
Creator Khushboo, Richa
Singh, Shanker K
Kumari, Sanju
Gulmire, Suraj K
Jaiswal, Amit
Srivastava, Mukesh
Kumar, Gulshan
 
Subject Acaricide, Dogs, Fluralaner, Sarcoptic mange, Sarcoptes scabiei, Scabies
 
Description Scabies, also known as sarcoptic mange, is a potentially contagious ectoparasitic disease that poses a threat to both human and animal health. The majority of conventional medications that are suggested for the treatment of sarcoptic mange require repeated administration over a period of several weeks and are regarded as harmful to both pets and pet owners. A recently developed long-acting oral ectoparasiticide of the isoxazoline class is called fluralaner. Therefore, the current study’s objective was to assess the therapeutic effects of a single dose of chewable fluralaner against canine sarcoptic mange. Nine dogs were enrolled who tested positive for Sarcoptes scabiei mite infestation and had a pinnal-pedal scratch reflex. The diseased dogs were given a single oral dose of fluralaner chewable at a rate of 25-56 mg/kg body weight. Six more healthy dogs were enrolled as healthy controls. Blood samples were collected from each diseased dog prior to the start of therapy and on day 21 post-therapy, and were used to analyse the haemato-biochemical changes. The haemato-biochemical panels of dogs with sarcoptic mange differed significantly from those of healthy dogs. None of the treated dogs had any S. scabiei mites on day 21 post-therapy. On day 21 post-therapy, it was found that the sarcoptes-induced skin lesions (SSLS) in dogs treated with fluralaner had improved by a total of 83.6 percent. Except for alanine aminotransferase (ALT), all altered haemato-biochemical panels of ill dogs returned to normalcy on day 21 following therapy. Fluralaner was found to be effective and safe enough to treat canine sarcoptic mange with a single oral dose. To corroborate the results of this study, additional research involving a large number of dogs with sarcoptic mange is required. 
 
Publisher Indian Society for Veterinary Medicine
 
Date 2024-02-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJVM/article/view/148356
 
Source Indian Journal of Veterinary Medicine; Vol. 42 No. 2 (2022)
0970-051X
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJVM/article/view/148356/53802
 
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