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Pharmacokinetics and bioavailability of ceftiofur following intravenous and intramuscular administrations in broiler chickens

Indian Agricultural Research Journals

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Title Pharmacokinetics and bioavailability of ceftiofur following intravenous and intramuscular administrations in broiler chickens
 
Creator ABOUBAKR, MOHAMED
ELBADAWY, MOHAMED
SOLIMAN, AHMED
SHAHEEN, HAZEM
ALKAFAFY, MOHAMED
ABDELMAGEED, NEHAL
ELSAYED, ASMAA
 
Subject Bioavailability, Ceftiofur sodium, Chickens, HPLC, Pharmacokinetics
 
Description The study focussed on pharmacokinetics and bioavailability of ceftiofur (CFT) after receiving a single dose (2 mg/kg BW) through either intravenous (IV) or intramuscular (IM) injection. Eight broiler chickens, were used in a crossover design with a washout period of two weeks to analyze the behaviour of CFT. Ceftiofur concentrations in the plasma were determined by HPLC with UV detector. The pharmacokinetics of CFT was analyzed using non- compartmental analysis. Following IV injection, CFT elimination half-life (t1/2β) was 2.43 h, volume of distribution at steady state (Vdss) was 0.63 L/kg, and total body clearance (Cl) was 0.24 L/h/kg. Following a single intramuscular (IM) injection of CFT at the same dose, the drug was quickly absorbed into the bloodstream with an absorption half- life (t1/2ab) of 0.31 h. The maximum concentration of the drug in the plasma (Cmax) was 2.85 μg/mL and reached at a time (Tmax) of 0.57 h after injection and the bioavailability (F) of CFT was 96.25%. The results of the study revealed that CFT was absorbed rapidly and showed high bioavailability when administered by IM route. This suggests that CFT has a promising disposition in chickens, and its use could help determine the best dosage regimens for effective eradication of various infections in chickens.
 
Publisher Indian Council of Agricultural Research
 
Date 2024-02-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/145678
10.56093/ijans.v94i2.145678
 
Source The Indian Journal of Animal Sciences; Vol. 94 No. 2 (2024); 112–116
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/145678/53819
 
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