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Facile synthesis, spectral characterization and biological evaluation of metal complexes comprising ((1-hydroxynaphthalen-2-yl) methyleneamino-cyclohexylimino-methyl)naphthalen-1-ol Schiff base ligand and assessing chemo pharmaceutical properties

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Title Facile synthesis, spectral characterization and biological evaluation of metal complexes comprising ((1-hydroxynaphthalen-2-yl) methyleneamino-cyclohexylimino-methyl)naphthalen-1-ol Schiff base ligand and assessing chemo pharmaceutical properties
 
Creator Priya, J
Manimalathi, S
Madheswari, D
 
Subject Antiproliferative activity
Antimicrobial activity
Chemopharmaceuticals
Molecular docking
Schiff base
 
Description 211-225
This work particularize a series of transition metal complexes such as Mn, Fe, Co, Ni, Cu and Zn, which have been synthesized from newly synthesized bidentate Schiff base ligand namely ((1-hydroxynaphthalen-2-yl)methyleneamino-cyclohexylimino-methyl)-naphthalen-1-ol and anticipated to evaluate the chemopharmaceutical properties of metal complexes. The Schiff base ligand and corresponding transition metal complexes have been characterized by spectral studies such as elemental analysis, UV-Vis, FT-IR, 1H NMR, 13C NMR spectroscopy and ESI mass spectrometry. Schiff base metal complexes have been screened for their in-vitro antimicrobial activities against bacterial and fungal strains in order to prove their biological activity. The theoretical molecular docking studies revealed the existence of favorable interaction between biomolecule and synthesized complexes. Outcome of the investigation proved that the transition metal complexes exhibited prominent activity towards MCF17 breast cancer tumor cell lines and therefore appropriate to design new therapeutic chemopharmaceuticals with vital applicability and good values of antiproliferative activity.
 
Date 2024-02-21T07:21:01Z
2024-02-21T07:21:01Z
2024-02
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63370
https://doi.org/10.56042/ijc.v63i2.3515
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(02) [Feb 2024]