ICAR Research Data Repository for Knowledge Management
A multi-centre study to evaluate the effect and safety of a classical Ayurveda medicine <em>Vyaghri Haritaki</em> in bronchial asthma
Online Publishing @ NISCAIR
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| Title Statement |
A multi-centre study to evaluate the effect and safety of a classical Ayurveda medicine <em>Vyaghri Haritaki</em> in bronchial asthma |
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| Added Entry - Uncontrolled Name |
Suryawanshi, Milind ; Regional Ayurveda Research Institute, KDK College Rd, Near Gharkul Parisar, Nandanvan, Nagpur, Maharashtra 440 009 Kumavat, Vinod Bihari; Regional Ayurveda Research Institute, Indira Colony, Jhotwara Road, Jaipur, Rajasthan 302 016 Dua, Pradeep ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Yadav, Babita ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Khanduri, Shruti ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Mundada, Pallavi ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Singhal, Richa ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Rana, Rakesh Kumar; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 Bharti, Bharti ; Central Ayurveda Research Institute, Road No.66, West Punjabi Bagh, Punjabi Bagh, New Delhi, Delhi 110 026 Srikanth, Narayanam ; Central Council for Research in Ayurvedic Sciences, Opposite ‘D’ Block, Janakpuri, New Delhi 110 058 |
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| Uncontrolled Index Term |
Avaleha, FEV1, PEFR, Polyherbal, Respiratory disorders, Tamak Swasa, Vyaghri haritaki |
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| Summary, etc. |
Bronchial asthma (vis-à-vis <em>Tamaka Swasa</em> in Ayurveda) is a chronic inflammatory disorder of the airway. Multiple Ayurvedic formulations are prescribed by Ayurveda physicians for <em>Tamak Swasa</em>. <em>Vyaghri Haritaki</em> is one such commonly prescribed poly herbal classical Ayurvedic formulation. A<strong> </strong>multicentre single-arm study was conducted at three Ayurveda Research Institutes in India to explore the effect and tolerability of <em>Vyaghri Haritaki</em>, a classical Ayurvedic medicine, on bronchial asthma (<em>Tamaka Swasa</em>). One forty seven patients between 18 and 60 years diagnosed with bronchial asthma showing a positive test of reversibility of airway obstruction were enrolled. Patients with peak expiratory flow rate (PEFR) < 50% and/ or forced expiratory volume in the first second (FEV1) < 50% of the predicted value and other major co-morbidities were excluded. 10 g <em>Vyaghri Haritaki</em> twice a day with lukewarm water was given for 12 weeks (84 days). Changes in the clinical symptoms (Asthma Control Questionnaire), quality of life (St. George Respiratory Questionnaire), respiratory function (peak expiratory flow rate and forced expiratory volume in one second), and haematological and biochemical parameters were compared before and after the treatment. Data of 142 participants were analysed which revealed significant improvement in PEFR [Baseline 301.7 litre/minute and 84<sup>th</sup> Day 334.85 litre/minute (<em>p</em><0.001)], FEV1 [Baseline 1.83 litres and 84<sup>th</sup> Day 2.12 litres (<em>p</em><0.001)], Asthma Control Questionnaire [Baseline 2.95 and 84<sup>th</sup> Day 1.43 (<em>p</em><0.001)], and the total score of the St. George Respiratory Questionnaire [Baseline 50.46 and 84<sup>th</sup> Day 30.74 (<em>p</em><0.001)]. No adverse events were reported during the study. <em>Vyaghri Haritaki</em> may<strong> </strong>prove beneficial in improving the pulmonary function, overall symptoms, and quality of life of patients with bronchial asthma which is well tolerated. |
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| Publication, Distribution, Etc. |
Indian Journal of Traditional Knowledge (IJTK) 2024-02-22 12:01:30 |
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| Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJTK/article/view/72509 |
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| Data Source Entry |
Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 2 (2024): Indian Journal of Traditional Knowledge |
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| Language Note |
en |
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