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<p>Antifertility activity of <em>Oroxylum indicum</em> Vent. stem bark on female Wistar rats</p>

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Title Statement <p>Antifertility activity of <em>Oroxylum indicum</em> Vent. stem bark on female Wistar rats</p>
 
Added Entry - Uncontrolled Name Das, Banani ; Assam University, Silchar, India -788011
Mahapatra, Madhusmita ; Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India), 5th Mile, NH-10A, Near Metro Point, Tadong, Gangtok, Sikkim, North-East India -737102
Gurung, Bhumika ; Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India), 5th Mile, NH-10A, Near Metro Point, Tadong, Gangtok, Sikkim, North-East India -737102
Dey, Amitabha ; Institute of Bioresources and Sustainable Development (IBSD), An autonomous Institute of Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur. 795001
Nongalleima, Khumukcham ; Institute of Bioresources and Sustainable Development (IBSD), An autonomous Institute of Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur. 795001
Das, Supriya ; Institute of Pharmacy, Harish Chandra PG College, Varanasi, Uttar Pradesh-221002.
Talukdar, Anupam Das; Assam University, Silchar, India -788011
Chowdhury, Abhishek ; Assam University, Silchar, India -788011
Choudhury, Manabendra Dutta; Assam University, Silchar, India -788011
Deb, Lokesh ; Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India),
Department of Biotechnology - Institute of Bioresources and Sustainable Development (IBSD), Government of India, Imphal, Manipur
 
Uncontrolled Index Term Antifertility agent; Contraceptive; Medicinal plants; Oroxylum indicum (L.) Vent.; North East India; Tripura; Manipur
 
Summary, etc. <p>Plant based traditional medicines are being used by the diversified populations of North-East India (NE India) for numerous human ailments and birth control since ancient times. Different ethnic communities of the Indian state Tripura have been traditionally using fresh stem bark of <em>Oroxylum indicum </em>(L.) Vent. for birth control. Thus, the aim of this research was to justify pharmacologically the traditional use of <em>Oroxylum indicum</em> stem bark for birth control. The <em>ex-vivo</em> uterotonic potential of four different extracts <em>viz</em>., ethyl acetate (EAOI), acetone (ACOI), methanolic (MEOI) and aqueous (AEOI) extracts (10 μg/50 µL) of <em>O. indicum</em> stem bark was carried out using uterine tissue and 4%, 16%, 53% and 89% uterine contraction, respectively was observed. Hence, 200 mg/kg/day dose of MEOI and AEOI were investigated on female rats for <em>in-vivo</em> abortifacient and anti-implantation activity and the level of different hormones released were estimated. In addition, acute-toxicity of the MEOI and AEOI were carried out on rats of either sex. The AEOI extract showed height potential for both aborticide (**p&lt;0.01) and anti-implantation effect (**p&lt;0.01) in compared to MEOI extract. It was noticed that there was a significant decline (**p&lt;0.01) in gonadotropic releasing hormone (GnRH) level in anti-implantation model and major elevation (**p&lt;0.01) in luteinizing hormone (LH) level of anti-implantation and abortifacient model in both standard and treatment group, where Ethinylestradiol (0.1 mg/kg/day, P.O.) used in standard group and the treatment group received AEOI. In acute toxicity studies, both the test samples of MEOI and AEOI have not exhibited any toxic effect up to 2000 mg/kg dose. Based on the pharmacological aspect, the present study justifies the traditional claim for <em>O. indicum </em>as an antifertility agent and identifies the potential of AEOI as an excellent and safe source of antifertility agent.</p><br />
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-02-22 12:01:30
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/45737
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 2 (2024): Indian Journal of Traditional Knowledge
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/45737/465546712
http://op.niscair.res.in/index.php/IJTK/article/download/45737/465546713
http://op.niscair.res.in/index.php/IJTK/article/download/45737/465546715