Antifertility activity of Oroxylum indicum Vent. stem bark on female Wistar rats
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Title |
Antifertility activity of Oroxylum indicum Vent. stem bark on female Wistar rats
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Creator |
Das, Banani
Mahapatra, Madhusmita Gurung, Bhumika Dey, Amitabha Nongalleima, Khumukcham Das, Supriya Talukdar, Anupam Das Chowdhury, Abhisheck Choudhury, Manabendra Dutta Deb, Lokesh |
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Subject |
Antifertility agent
Contraceptive Medicinal plants Oroxylum indicum (L.) Vent. |
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Description |
189-199
Plant based traditional medicines are being used by the diversified populations of North-East India (NE India) for numerous human ailments and birth control since ancient times. Different ethnic communities of the Indian state Tripura have been traditionally using fresh stem bark of Oroxylum indicum (L.) Vent. for birth control. Thus, the aim of this research was to justify pharmacologically the traditional use of Oroxylum indicum stem bark for birth control. The ex-vivo uterotonic potential of four different extracts viz., ethyl acetate (EAOI), acetone (ACOI), methanolic (MEOI) and aqueous (AEOI) extracts (10 μg/50 μL) of O. indicum stem bark was carried out using uterine tissue and 4%, 16%, 53% and 89% uterine contraction, respectively was observed. Hence, 200 mg/kg/day dose of MEOI and AEOI were investigated on female rats for in-vivo abortifacient and anti-implantation activity and the level of different hormones released were estimated. In addition, acute-toxicity of the MEOI and AEOI were carried out on rats of either sex. The AEOI extract showed height potential for both aborticide (**p |
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Date |
2024-02-22T11:03:33Z
2024-02-22T11:03:33Z 2024-02 |
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Type |
Article
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Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63380 https://doi.org/10.56042/ijtk.v23i2.8722 |
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Language |
en
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Relation |
Int Cl.24: A61K 36/00
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Publisher |
NIScPR-CSIR,India
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Source |
IJTK Vol.23(2) [February 2024]
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