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Antifertility activity of Oroxylum indicum Vent. stem bark on female Wistar rats

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Title Antifertility activity of Oroxylum indicum Vent. stem bark on female Wistar rats
 
Creator Das, Banani
Mahapatra, Madhusmita
Gurung, Bhumika
Dey, Amitabha
Nongalleima, Khumukcham
Das, Supriya
Talukdar, Anupam Das
Chowdhury, Abhisheck
Choudhury, Manabendra Dutta
Deb, Lokesh
 
Subject Antifertility agent
Contraceptive
Medicinal plants
Oroxylum indicum (L.) Vent.
 
Description 189-199
Plant based traditional medicines are being used by the diversified populations of North-East India (NE India) for
numerous human ailments and birth control since ancient times. Different ethnic communities of the Indian state Tripura
have been traditionally using fresh stem bark of Oroxylum indicum (L.) Vent. for birth control. Thus, the aim of this research
was to justify pharmacologically the traditional use of Oroxylum indicum stem bark for birth control. The ex-vivo uterotonic
potential of four different extracts viz., ethyl acetate (EAOI), acetone (ACOI), methanolic (MEOI) and aqueous (AEOI)
extracts (10 μg/50 μL) of O. indicum stem bark was carried out using uterine tissue and 4%, 16%, 53% and 89% uterine
contraction, respectively was observed. Hence, 200 mg/kg/day dose of MEOI and AEOI were investigated on female rats for
in-vivo abortifacient and anti-implantation activity and the level of different hormones released were estimated. In addition,
acute-toxicity of the MEOI and AEOI were carried out on rats of either sex. The AEOI extract showed height potential for
both aborticide (**p
 
Date 2024-02-22T11:03:33Z
2024-02-22T11:03:33Z
2024-02
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63380
https://doi.org/10.56042/ijtk.v23i2.8722
 
Language en
 
Relation Int Cl.24: A61K 36/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(2) [February 2024]