Assessing safety, efficacy and residue depletion in golden mahseer, Tor putitora (Hamilton, 1822): biochemical and physiological responses to graded concentrations of oxytetracycline dietary supplementation
KRISHI: Publication and Data Inventory Repository
View Archive InfoField | Value | |
Title |
Assessing safety, efficacy and residue depletion in golden mahseer, Tor putitora (Hamilton, 1822): biochemical and physiological responses to graded concentrations of oxytetracycline dietary supplementation
Not Available |
|
Creator |
Sumanta Kumar Mallik
Prasanna Kumar Patil Neetu Shahi Ritesh Shantilal Tandel Amit Pande |
|
Subject |
Aeromonas hydrophila · Biological response · Golden mahseer · Oxytetracycline dihydrate · Efficacy · Non- specific immune response · Residue depletion
|
|
Description |
Not Available
The safety and effectiveness of oxytetracycline can potentially manage bacterial infections in fish. This, in turn, might reduce the concerns related to its use in aquaculture and human consumption, such as toxicity, antimicrobial resistance, and other associated risks. The primary objective of this study was to assess how adding oxytetracycline dihydrate to the diet affects its effectiveness, safety, and the presence of residues in T. putitora. T. putitora fingerlings, subjected to experimental infection with Aeromonas hydrophila at a concentration of 108 CFU mL−1 , received an oral administration of oxytetracycline dihydrate. The oxytetracycline dihydrate was added to the feed (corresponding to 2% of the fish body weight) at concentrations of 44.1, 88.2, 132.3 and 176.4 mg Kg−1 fish body weight per day. This treatment was carried out for 10 consecutive days. The biochemical and physiological responses of T. putitora and efficacy of oxytetracycline dihy- drate were determined through estimation of microbial load (CFU mL−1 ), haematogram, serum biomarkers, behavioral characteristics, non-specific immunity and residue depletion. Experimentally infected fish showed disease progression and induced histopathological conditions with highest microbial load (CFU mL−1 ) in the muscle of both control and treated fish. The fish haematogram showed increased leucocyte and haemoglobin content, influenced by dietary oxytetracycline dihydrate. The fish demonstrated adaptive physiological response to oxytetracycline dihydrate at 44.1 to 88.2 mg and resulted in increased albumin and globulin content. The serum-enzyme assay showed significant increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma alkaline phosphatase (ALP) activities in the test fish ( Not Available |
|
Date |
2024-02-28T20:21:49Z
2024-02-28T20:21:49Z 2024-02-22 |
|
Type |
Research Paper
|
|
Identifier |
Not Available
https://doi.org/10.1007/s11259-024-10340-0 http://krishi.icar.gov.in/jspui/handle/123456789/81525 |
|
Language |
English
|
|
Relation |
Not Available;
|
|
Publisher |
Springer
|
|