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Assessing safety, efficacy and residue depletion in golden mahseer, Tor putitora (Hamilton, 1822): biochemical and physiological responses to graded concentrations of oxytetracycline dietary supplementation

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Title Assessing safety, efficacy and residue depletion in golden mahseer, Tor putitora (Hamilton, 1822): biochemical and physiological responses to graded concentrations of oxytetracycline dietary supplementation
Not Available
 
Creator Sumanta Kumar Mallik
Prasanna Kumar Patil
Neetu Shahi
Ritesh Shantilal Tandel
Amit Pande
 
Subject Aeromonas hydrophila · Biological response · Golden mahseer · Oxytetracycline dihydrate · Efficacy · Non- specific immune response · Residue depletion
 
Description Not Available
The safety and effectiveness of oxytetracycline can potentially manage bacterial infections in fish. This, in turn, might
reduce the concerns related to its use in aquaculture and human consumption, such as toxicity, antimicrobial resistance,
and other associated risks. The primary objective of this study was to assess how adding oxytetracycline dihydrate to
the diet affects its effectiveness, safety, and the presence of residues in T. putitora. T. putitora fingerlings, subjected to
experimental infection with Aeromonas hydrophila at a concentration of 108
CFU mL−1

, received an oral administration
of oxytetracycline dihydrate. The oxytetracycline dihydrate was added to the feed (corresponding to 2% of the fish body
weight) at concentrations of 44.1, 88.2, 132.3 and 176.4 mg Kg−1

fish body weight per day. This treatment was carried out

for 10 consecutive days. The biochemical and physiological responses of T. putitora and efficacy of oxytetracycline dihy-
drate were determined through estimation of microbial load (CFU mL−1

), haematogram, serum biomarkers, behavioral
characteristics, non-specific immunity and residue depletion. Experimentally infected fish showed disease progression and
induced histopathological conditions with highest microbial load (CFU mL−1

) in the muscle of both control and treated
fish. The fish haematogram showed increased leucocyte and haemoglobin content, influenced by dietary oxytetracycline
dihydrate. The fish demonstrated adaptive physiological response to oxytetracycline dihydrate at 44.1 to 88.2 mg and
resulted in increased albumin and globulin content. The serum-enzyme assay showed significant increase in aspartate
aminotransferase (AST), alanine aminotransferase (ALT) and plasma alkaline phosphatase (ALP) activities in the test fish
(
Not Available
 
Date 2024-02-28T20:21:49Z
2024-02-28T20:21:49Z
2024-02-22
 
Type Research Paper
 
Identifier Not Available
https://doi.org/10.1007/s11259-024-10340-0
http://krishi.icar.gov.in/jspui/handle/123456789/81525
 
Language English
 
Relation Not Available;
 
Publisher Springer