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Cyclophosphamide Induced Testicular Toxicity Mechanisms aAnd Ameliorative Agents

Indian Agricultural Research Journals

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Title Cyclophosphamide Induced Testicular Toxicity Mechanisms aAnd Ameliorative Agents
 
Creator Matam SriDeepthi
Kondampati Kasturi Devi
Matukuamli Usha rani
Boinepally Ramya
Beesam Srinu
 
Subject Cyclophosphamide, Testicular toxicity, Oxidative stress, Antioxidants
 
Description Cyclophosphamide is an alkylating agent that is widely known for its anticancer and immunosuppressive properties used in various cancerous and autoimmune diseases. Acrolein and phosphoramide mustard, are its toxic metabolites, majorly involved in toxic effects such as induction of oxidative stress that can induce oxidative damage in tissues. The free radicles thus produced are implicated in gonad toxicity, hepatic and kidney disorders, hemorrhagic cystitisetc. Clinical efficacy of cyclophosphamide is restricted because of its toxicity. The reproductive system due to presence of rapidly dividing cells is highly vulnerable to cyclophosphamide toxicity. Especially male subjects treated with cyclophosphamide demonstrated severe alterations in testis and epididymis as well as disturbed gonadotropin and reproductive hormone levels. Several studies suggested the usage of medicinal plants with antioxidant properties along with cyclophosphamide could protect against its organ toxicity. Supplementation of the dietary antioxidant’s during chemotherapy can reduce the drug induced toxic side effects and can further improvise the response to therapy.
 
Publisher Indian Veterinary Association
 
Date 2024-02-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IVJ/article/view/148862
10.62757/IVA.2024.101.2.61-67
 
Source The Indian Veterinary Journal; Vol. 101 No. 2 (2024): February 2024; 61 - 67
0974-9365
0019-6479
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IVJ/article/view/148862/54006
 
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