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Vitamin D Receptor Renewal Through Anti-inflammatory Diet: (Another Contributing Factor for Vitamin D Resistance)

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Vitamin D Receptor Renewal Through Anti-inflammatory Diet: (Another Contributing Factor for Vitamin D Resistance)
 
Identifier https://doi.org/10.7910/DVN/LC0RXO
 
Creator Dr. Eduardo Beltran
 
Publisher Harvard Dataverse
 
Description Vitamin D is an essential nutrient that plays a crucial role in maintaining bone health, immune function, and overall health. Adequate levels of vitamin D are important for proper calcium absorption, regulation of gene expression, and modulation of immune responses. However, patients with autoimmune diseases may have genetic polymorphisms that contribute to vitamin D resistance, such as single nucleotide polymorphisms (SNPs) affecting the genes CYP2R1, CYP27B1, VDR, and VDBP.

In addition, these patients may have ongoing leaky gut syndrome due to inflammatory foods, such as gluten, dairy, lectins, and sugars, which can lead to molecular mimicry and the production of autoantibodies. This condition sets the stage for foreign proteins and toxins, including lipopolysaccharides, endotoxins, exotoxins, and mycotoxins, to enter the bloodstream, further inducing the production of autoantibodies.

Bacterial, fungal, and viral infections can also contribute to vitamin D resistance by downregulating the expression of vitamin D receptors, and this mechanism is often overlooked. For instance, studies have shown that some viruses, such as HIV, HSV1, HCV, and EBV, can suppress VDR expression and vitamin D signaling pathways, leading to decreased immune response and increased viral replication

Understanding the mechanisms by which these toxins and infections impact vitamin D receptor expression, end up creating a contributing factor for vitamin D resistance that is sometimes overlooked on behalf healthcare providers. Additionally, we have learned a great deal from high dose vitamin D therapy supplementation alongside anti- inflammatory dietary which has been shown to reduce degree of dysbiosis and intestinal permeability giving time for our cells to in order to upregulate VDRs in our immune cells and restore our immunologic tolerance once again.
 
Subject Medicine, Health and Life Sciences
Vitamin D, VDR, Vitamin D Receptor, Anti-inflammatory Diet, High Dose Vitamin D, Herbal Antimicrobials
 
Date 2024-01-18
 
Contributor Beltran, Eduardo