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Computational model of striosomal circuit in normal and disordered decision-making

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Computational model of striosomal circuit in normal and disordered decision-making
 
Identifier https://doi.org/10.7910/DVN/SMKW0I
 
Creator Beck, Dirk W.
Rakocevic, Lara I.
Heaton, Cory N.
Davila, Luis D.
Drammis, Sabrina M.
Hossain, Safa B.
Giri, Atanu
Salcido, Alexis A.
Reyes, Neftali F.
Batson, Serina A.
Macias, Andrea Y.
Vara, Paulina
Qingyang, Zhang
Umashankar Beck, Shreeya
Negishi, Kenichiro
Ibanez-Alcala, Rodrigo J.
Waller, Graham L.
Tyulmankov, Danil
Pokojovy, Michael
O'Dell, Laura E.
Moschak, Travis M.
Goosens, Ki A.
Friedman, Alexander
 
Publisher Harvard Dataverse
 
Description The striosomal and matrix compartments of the striatum and the regions to which they project are critical in decision-making, including irrational choices, a transdiagnostic symptom across psychiatric disorders. We propose a biologically-realistic computational model that suggests a mechanism for interaction between the striosomes-matrix, direct-indirect pathways, and dopamine-lateral habenula regions during decision-making. Our three-layered model validates experimental results obtained from: circuit recordings during decision-making, physiological recordings from brain slices, and decision-making phenotypes measured on animals and humans. It makes experimentally-testable predictions regarding shifts of circuit balances that create transdiagnostic symptoms across psychiatric disorders including post-traumatic stress disorder and substance abuse. It also explains the distinct role of each circuit component in producing decisions in disordered and non-disordered decision-making states, such as the role of the striosomal circuit in mediating decision-making accuracy and time-to-decision. This theory of mechanistic neural circuit interactions advances understanding of psychiatric disorders and the development of bioinformed treatments.
 
Subject Medicine, Health and Life Sciences
 
Date 2024-02-21
 
Contributor Davila, Luis