Evaluation of codon usage patterns and molecular evolution dynamics in Japanese encephalitis virus: An integrated bioinformatics approach
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Title |
Evaluation of codon usage patterns and molecular evolution dynamics in Japanese encephalitis virus: An integrated bioinformatics approach
Not Available |
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Creator |
Suresh KP
Indrabalan UB Shreevatsa B Dharmashekar C Singh P Patil SS Syed A Elgorban AM Eswaramoorthy R Amachawadi RG Shivamallu C |
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Subject |
Codon usage
Japanese encephalitis Molecular evolutionary dynamics Phylogeography Selection pressure |
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Description |
Not Available
In the recent survey, Japanese encephalitis (JE) is one of the most common mosquito-borne diseases, accounting for ∼30% of fatalities. The outbreaks of the JE virus (JEV) suggests that exhaustive study is essential for the prevention and management of the disease. The disease mainly spreads in humans and pigs by the vector: mosquito; as this is a major concern, this study had employed various bioinformatics tools to investigate the codon usage bias, evolutionary inference and selection pressure analysis of the Japanese encephalitis virus disease. The results indicated that the JE virus was biased and natural selection was the main factor shaping the codon usage that was determined and confirmed with the Nc, neutrality, PR2 plots and correlation analysis. The evolutionary analysis revealed that the virus had a substitution rate of 1.54 × 10-4 substitution/site/year and the tMRCA was found to be in 1723. The transmission of the virus in the map found transmissions mostly from China and transmitted across Asia and Africa. The selection pressure analysis employed three methods which had 969th codon site as diversifying site and had many purifying sites that shows the virus had evolved rapidly. The inferences from this study would aid people to employ this methodology on various diseases and also perform insilico studies in the field of vaccinology and immunoinformatics. Not Available |
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Date |
2024-03-06T16:19:18Z
2024-03-06T16:19:18Z 2023-02-13 |
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Type |
Research Paper
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Identifier |
37. Suresh, K.P., Indrabalan, U.B., Shreevatsa, B., Dharmashekar, C., Singh, P., Patil, S.S., Syed, A., Elgorban, A.M., Eswaramoorthy, R., Amachawadi, R.G. and Shivamallu, C. (2023). Evaluation of codon usage patterns and molecular evolution dynamics in Japanese encephalitis virus: An integrated bioinformatics approach. Infection, Genetics and Evolution, 109: 105410.
1567-1348 http://krishi.icar.gov.in/jspui/handle/123456789/81613 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier Publications
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