Record Details

Druggability of lead compounds from turnleric (Curcuma longa)

DSpice at Indian Institute of Spices Research

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Field Value
 
Creator WILSON, M
BALAJI, S
EAPEN, S J
 
Date 2014-08-02T08:40:04Z
2014-08-02T08:40:04Z
2006
 
Identifier Journal of Medicinal and Aromatic Plant Sciences 28 (2006) 384-390
http://hdl.handle.net/123456789/1150
 
Description Curcumin (diferuloylmethane), the main bioactive component of turmeric, has been proved to have a wide spectrum of
biological actions through several pharmacological studies. However, cheminformatics approaches are seldom used in these studies. In silico approaches can help in identifylng better drug
candidates that are safe, besides cutting down the high costs. In this study, in silico tools were applied to chemical compounds In turmeric for the first time to predict their biological activities
and druggability. The druggability of these compounds was checked by using the Lipinski's scoring functions such as Log
P, molecular weight, number of hydrogen bond donors and number of hydrogen bond acceptors. The results of these in
silico studies indicate that, in contrast to curcumin, several other compounds in turmeric exhibit better activities which
have to be confirmed by both pharmacological and clinical studies.
 
Format 454969 bytes
application/pdf
 
Language en
 
Subject Druggability
Turmeric
virtual screening
PASS prediction
 
Title Druggability of lead compounds from turnleric (Curcuma longa)
 
Type Article