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Joint linkage–linkage disequilibrium mapping is a powerful approach to detecting quantitative trait loci underlying drought tolerance in maize

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Relation http://oar.icrisat.org/164/
http://dx.doi.org/10.1073/pnas.1006105107
 
Title Joint linkage–linkage disequilibrium mapping is a powerful approach to detecting quantitative trait loci underlying drought tolerance in maize
 
Creator Yanli, Lu
Shihuang, Zhang
Trushar, Shah
Chuanxiao, Xie
Zhuanfang, Hao
Xinhai, Li
Farkhari, Md
Jean-Marcel, Ribaut
Moju, Cao
Tingzhao, Rong
Yunbi, Xu
 
Subject Maize
 
Description This paper describes two joint linkage–linkage disequilibrium (LD) mapping approaches: parallel mapping (independent linkage and LD analysis) and integrated mapping (datasets analyzed in combination). These approaches were achieved using 2,052 single nucleotide polymorphism (SNP) markers, including 659 SNPs developed from drought-response candidate genes, screened across three recombinant inbred line (RIL) populations and 305 diverse inbred lines, with anthesis-silking interval (ASI), an important trait for maize drought tolerance, as the target trait. Mapping efficiency was improved significantly due to increased population size and allele diversity and balanced allele frequencies. Integrated mapping identified 18 additional quantitative trait loci (QTL) not detected by parallel mapping. The use of haplotypes improved mapping efficiency, with the sum of phenotypic variation explained (PVE) increasing from 5.4% to 23.3% for single SNPbased analysis. Integrated mapping with haplotype further improved the mapping efficiency, and the most significant QTL had a PVE of up to 34.7%. Normal allele frequencies for 113 of 277 (40.8%) SNPs with minor allele frequency (
 
Publisher National Academy of Sciences
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://oar.icrisat.org/164/1/new17.pdf
Yanli, Lu and Shihuang, Zhang and Trushar, Shah and Chuanxiao, Xie and Zhuanfang, Hao and Xinhai, Li and Farkhari, Md and Jean-Marcel, Ribaut and Moju, Cao and Tingzhao, Rong and Yunbi, Xu (2010) Joint linkage–linkage disequilibrium mapping is a powerful approach to detecting quantitative trait loci underlying drought tolerance in maize. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490, 1. pp. 1-6.