ICAR Research Data Repository for Knowledge Management

This is a replication dataset for the manuscript titled: "Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision."

This dataset contains complete blood count data (platelet counts and total white blood cell counts) for severely ill patients enrolled in either studies of severe malaria or general severe febrile illness in Africa and Asia. For reproducibility of analyses we also provide parasite densities; hospital outcome; sickle trait status for the Kenyan children; plasma PfHRP2 for FEAST and Bangladesh adults; age.

Variable Description:

study: Vietnam (2 randomized trials in severe malaria: Hien et al; Phu et al); Bangladesh/Thailand (observational studies in severe malaria); FEAST (Maitland et); Kenya (KEMRI severe malaria cohort)

platelets: number of platelets x1000 per uL of blood

wbc: number of white blood cells x1000 per uL of blood

pfhrp2: PfHRP2 concentration in plasma (ng/mL)

age: years

HbAS: sickle trait genotype (0: not sickle trait; 1: sickle trait)

outcome: in hospital survival (0: survived; 1: died)

parasitaemia: parasite density per uL of blood.

The package presented contains data and replication code. The code is also available on github repo: code is on this github repo: https://github.com/jwatowatson/Kenyan_phenotypic_accuracy