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Synthesis of process related impurities of Citicoline and Citicoline sodium

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Field Value
 
Title Synthesis of process related impurities of Citicoline and Citicoline sodium
 
Creator Pakhurde, Amit H
More, Priyanka S
Bonde, Nilesh L
Kotharkar, Sandeep A
 
Subject Citicoline
Citicoline sodium
Cytidine
Cytidine-5′-monophosphate
Impurities
 
Description 304-314
Citicoline is the diphosphate ester of cytidine. The said compound is sensitive to chemical atmosphere and exhibits
formation of process/degradation impurities. Herein is reported a comprehensive synthesis of the pharmacopeia impurities
of Citicoline and Citicoline sodium with an objective to provide impurities for better understanding and control in the
Citicoline preparation process. This report provides synthetic methodologies for the impurities, considering ease of
handling, chemistry and eliminating tedious purification. All the impurities are characterized and the structures confirmed.
 
Date 2024-03-19T11:06:54Z
2024-03-19T11:06:54Z
2024-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63590
https://doi.org/10.56042/ijc.v63i3.6700
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(03) [March 2024]