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Synthesis, spectral analysis and in vitro anticancer activity of 1,2,3-triazole derivatives and their molecular docking studies

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Title Synthesis, spectral analysis and in vitro anticancer activity of 1,2,3-triazole derivatives and their molecular docking studies
 
Creator Manasa, Guttikonda
Nukala, Satheesh Kumar
 
Subject Triazole
1,3-Dipolar cycloaddition
Click reaction
Anticancer activity
 
Description 286-292
Triazole derivatives are an absolutely essential class of compounds as they are involved in such a diverse range of
pharmacological effects. In the field of medical chemistry, these nitrogen-containing heterocycles are used in the role of
therapeutic medicines. The molecule with the given name has been synthesized by using click chemistry [Copper-Catalyzed
Azide-Alkyne Cycloaddition (CuAAC)] with 1-propargyl-6-methoxy benzimidazolone as the dipolarophile and benzylazide
as the dipole. A majority of the compounds show moderate to excellent efficacy when tested for anticancer properties
against several cancer cell lines. The MCF-7 cell line is the most resistant to compounds 1a and 1e, with an IC50 value of
1.82 and 1.90 μM respectively. In contrast, the MDA - MB-231 and HeLa cell lines respond favorably to compounds IVb,
IVc and IVd. Compound IVa is docked in the active site with EGFR as the target molecule. 1H and 13C NMR, IR and ESIHRMS
have been used to determine the structures of the newly synthesized compounds.
 
Date 2024-03-19T11:09:48Z
2024-03-19T11:09:48Z
2024-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63592
https://doi.org/10.56042/ijc.v63i3.6682
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(03) [March 2024]