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Synthesis of some benzocoumarin and benzochromone: Antielastase, antihyaluronidase, anticollagenase and antidiabetic activities and in silico ADME and molecular docking studies

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Title Synthesis of some benzocoumarin and benzochromone: Antielastase, antihyaluronidase, anticollagenase and antidiabetic activities and in silico ADME and molecular docking studies
 
Creator Ertik, Onur
Kolancılar, Hakan
Yanardag, Refiye
 
Subject Benzocoumarin
Benzochromone
Enzyme inhibition
Molecular docking
ADME
 
Description 253-262
Coumarins are compounds commonly found in nature and have many biological effects. So it is a molecule that continues to
be popular. Benzocoumarin and benzochromone, which are coumarin derivatives, are a group of molecules obtained from
plants and it is important to understand the biological activity of the derivatives of these molecules. In our study, the inhibitory
effects of newly synthesized 9-hydroxy-1-methyl-3H-naphto[2,1-b]piran-3-on (benzocoumarin)(1) and 9-hydroxy-2-methyl-
4H-naphto[2,1-b]piran-4-on (benzochromone)(2) on elastase, hyaluronidase, collagenase, alpha-amylase, and alpha-glucosidase
were investigated. As a result of in vitro studies, the inhibition effect of compounds 1 (132.64±16.12 μM) and 2 (400.25±64.77
μM)), was observed relative to the dose, only the inhibition effect on collagenase was found to have a lower IC50 value than the
positive control (479.03±38.40 μM). In line with the data obtained as a result of in vitro studies, molecular docking studies were
also carried out for compounds 1 and 2 with collagenase. As a result, due to the inhibitory effect of compounds 1 and 2 on the
collagenase activity, a way has been opened for further studies to prove it.
 
Date 2024-03-19T11:17:07Z
2024-03-19T11:17:07Z
2024-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63597
https://doi.org/10.56042/ijc.v63i3.5887
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(03) [March 2024]