Record Details

Evaluation of Robusta Coffee Bean Extract (Coffea canephora) Efficacy as an Antioxidant in Mitigating Lead Acetate (Pb) Induced Alterations in Villi Epithelial Height and Duodenum Crypts Depth in Rats (Rattus norvegicus)

Indian Agricultural Research Journals

View Archive Info
 
 
Field Value
 
Title Evaluation of Robusta Coffee Bean Extract (Coffea canephora) Efficacy as an Antioxidant in Mitigating Lead Acetate (Pb) Induced Alterations in Villi Epithelial Height and Duodenum Crypts Depth in Rats (Rattus norvegicus)
 
Creator Indaka Rachmah Choirunnisa
Aminullah Alhady Chozin
Fania Aulia Rahma
Farodina Azka Zhafira
Moch. Ilham Riza Fahlefi
Maya Nurwartanti Yunita
Bodhi Agustono
Md. Aliar Rahman
Reina Puspita Rahmaniar
 
Subject Coffea canephora, duodenum, health, lead acetate
 
Description Exposure to lead acetate in the long term can cause health problems and cell damage. This study was conducted to determine the effectiveness of post-administration of lead acetate with robusta coffee bean extract (Coffea canephora) on the histotoxicity of the duodenum in25male Wistarrats (Rattus norvegicus) Wistar strain. The study included five treatment groups: K(-) as the negative control, K(+) with oral exposure to 2 mg/kg body weight of lead acetate, and P(1), P(2), and P(3) receiving 2 mg/kg body weight of lead acetate followed by robusta coffee bean extract (Coffeacanephora) at doses of 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively. Each group comprised five rats. The investigation aimed to assess the dose-dependent protective effects of the coffee bean extract on villi epithelial height and duodenum crypts depth in rats (Rattus norvegicus) exposed to lead acetate and the data were analyzed statistically using the Kruskal-Wallis test. Measurement of villi height and duodenal crypt depth in this study showed that the antioxidant effect of robusta coffee bean extract (Coffea canephora), given in doses of 200, 400, and 800 mg/kg BW that caused by lead acetate showed an increase in mean villi height and an increase in mean crypt depth although not significant in reducing duodenal damage.
 
Publisher Indian Veterinary Association
 
Date 2024-03-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IVJ/article/view/150040
 
Source The Indian Veterinary Journal; Vol. 101 No. 03 (2024): March, 2024; 7-12
0974-9365
0019-6479
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IVJ/article/view/150040/54198
10.62757/IVA.2024.101.3.7-12
 
Rights Copyright (c) 2024 The Indian Veterinary Journal