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Oxidative stress in patients with osteoarthritis with infectious urinary tract: Approach through gene network analysis, urinary myeloperoxidase activity, and the oxidant/antioxidant status

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Title Oxidative stress in patients with osteoarthritis with infectious urinary tract: Approach through gene network analysis, urinary myeloperoxidase activity, and the oxidant/antioxidant status
 
Creator Demirhan, İlter
Öner, Erkan
Belge Kurutas, Ergül
 
Subject Gene set enrichment analysis (GSEA)
KEGG Pathway
 
Description 289-296
Determining MPO activity and oxidant/antioxidant (MDA, SOD and CAT) levels in the urine of osteoarthritis patients with
urinary infection was also performed for the first time to reveal the targets of gene enrichment network analysis of osteoarthritic
and urinary system-related genes. In addition, our other main goal was to learn that the use of computer-aided designs in this
study and other studies could help the target. Genes from patients with osteoarthritis and urinary infections were retrieved from
DisGENET. A venn Diagram was drawn for genes from DisGENET, and gene network analysis for common genes was done
with SRplot. 31 patients with concomitant osteoarthritis and urinary tract infection, 17 patients with osteoarthritis, 15 patients
with urinary tract infection and 25 healthy controls were included in the study. Urinary MPO, catalase (CAT), superoxide
dismutase (SOD), and malondialdehyde (MDA) levels were examined in a spectrophotometer as indicators of oxidant and
antioxidant status. Gene network analysis was performed for the first time for urinary infection and osteoarthritis, and
50 common genes were found. These common genes appear to be associated with arthritis, according to the KEGG pathway
result. In the osteoarthritis group, MPO activity and MDA levels were higher, and CAT and SOD levels were lower (P
 
Date 2024-03-27T05:13:52Z
2024-03-27T05:13:52Z
2024-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63618
https://doi.org/10.56042/ijeb.v62i04.401
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(04) [April 2024]