Record Details

Acute toxicity of bee venom from Apis mellifera L. in mice: A histopathological study

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Acute toxicity of bee venom from Apis mellifera L. in mice: A histopathological study
 
Creator Liu, Miaomiao
Huang, Li
Zhao, Shuguo
Lv, Jianhua
Zhao, Huiting
 
Subject Acute toxicity
Coagulation
Hemolysis
 
Description 273-280
Although the toxic effects of bee venom (BV) in humans are known, there are only a few systematic studies are available
in literature. Here, we have evaluated the potential toxicity of BV from Apis mellifera L. (Hymenoptera: Apidae) by studying
acute toxicity in mice receiving subcutaneous injections of high (120 mg/kg), medium (60 mg/kg) and low (8 mg/kg) doses
of BV. General toxicity symptoms and histopathological changes were recorded for 14 days. The results indicated that highdose
BV could be fatal. The mental state, appetite, and respiration of mice in the medium- and high-dose groups changed in
varying degrees; higher doses led to more prominent symptoms (LD50, 119.7 mg/kg). BV in medium- and high-dose groups
significantly inhibited weight gain in mice within 2 days, which did not significantly differ between the dose groups and
control at the later stage. The hemolysis rate was significantly higher in the low-dose, while in the medium- and high-dose
groups, the coagulation time significantly prolonged in male mice. Histopathological changes showed that medium- and
high-dose groups exhibited toxicity to tested organs. Our study showed that BV exhibited strong toxicity at higher
concentration and is relatively safe when the BV concentration is lower than 8 mg/kg.
 
Date 2024-03-27T05:45:54Z
2024-03-27T05:45:54Z
2024-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63620
https://doi.org/10.56042/ijeb.v62i04.3010
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(04) [April 2024]