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Role of SREBP and related molecules in the development of endometrial cancer

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Title Role of SREBP and related molecules in the development of endometrial cancer
 
Creator Antmen, Serife E.
Yalaza, Cem
Canacankatan, Necmiye
AYTAN, Hakan
Tuncel, Ferah
Erturk, Sema Erden
 
Subject Cholesterol
Endometrial adenocarcinoma
Gene expressions
Lipogenesis
Sterol regulatory element-binding proteins (SREBP)
 
Description 266-272
Oncogenic growth signal regulates glucose, glutamine and lipid metabolism to provide the bioenergy and biosynthetic requirements of rapidly dividing tumor cells. A class of membrane-bound transcription factors known as sterol regulatory element-binding proteins (SREBPs) activate the genes encoding the enzymes required to produce cholesterol and unsaturated fatty acids. In this study, we discussed the anticancer role of SREBP and its target genes, lipid and cholesterol metabolism enzymes in the development of endometrial cancer. This study comprised 45 patients with endometrial adenocarcinoma, who were further categorized into Grade 1 (n = 15), Grade 2 (n = 15), and Grade 3 (n = 15). The control group consisted of 29 endometrial tissues without an endometrial cancer diagnosis. SREBP, ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), acetyl CoA acetyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene expressions were examined using the real-time polymerase chain reaction (RT-PCR) method. The gene expressions of the patient group were higher than the control group (P
 
Date 2024-03-27T05:48:38Z
2024-03-27T05:48:38Z
2024-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63621
https://doi.org/10.56042/ijeb.v62i04.4909
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(04) [April 2024]