Record Details

<p><span lang="EN-GB">Reversal of restraint stress caused dendritic atropy in rats by <em>Nardostachys jatamansi</em></span></p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p><span lang="EN-GB">Reversal of restraint stress caused dendritic atropy in rats by <em>Nardostachys jatamansi</em></span></p>
 
Added Entry - Uncontrolled Name Shenoy, Bhasker K; Department of Applied Zoology, Mangalore University
Karkada, Gloria
S, Shruthi
NIL
 
Uncontrolled Index Term Dendritic atropy, Hippocampus, Nardostachys jatamansi, Neuron, Stress, Wistar rats
 
Summary, etc. <p>Hippocampus and prefrontal cortex of brain have distinct role in encoding and retrieval of memories. Uncontrollable stress may influence the structural alterations of limbic brain regions and atropy of neurons mainly in the regions like the prefrontal cortex and hippocampus. <em>Nardostachys jatamansi </em>(D. Don) DC (NJE) is a perennial herb and is known for its anti-Parkinson’s, hepatoprotective, neuroprotective, hypotensive and anti-diabetic activities. Even though, it is an effective therapeutic intervention for memory impairment but, its effect on the neurons of the hippocampus is not clear. In this context, the effect of NJE on chronic restraint stress induced dendritic atropy in rats was studied. Male Wistar rats underwent 21 days of restraint stress in a close fitting rodent restrainer. In combined treatment groups rats were treated with alcoholic extract of NJE at dosage of 200 mg/kg bw for 21 days along with chronic restraint stress. The dendritic morphology of neurons was studied in Golgi-impregnated sections. Stress produced dendritic atropy significantly increased the dendritic branching and intersections in experimental rats. Interestingly, treatment of stressed rats with NJE extract resulted in the reversal of stress induced the dendritic atrophy. These results demonstrate that atrophy of dendritic neurons caused by chronic restraint stress may be responsible for learning and memory impairment. Co-treatment of rats with NJE showed enhancement in the dendritic branching in the hippocampus. Furthermore, NJE treatment significantly increased superoxide dismutase activity and total antioxidant capacity in frontal cortex, hippocampus and striatum regions of brain. Thus, our findings suggest that NJE is a potential neuroprotector, which might be beneficial in the treatment of stress induced memory impairment.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-04-12 11:28:21
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/47449
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 4 (2024): Indian Journal of Traditional Knowledge
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/47449/465553520
http://op.niscair.res.in/index.php/IJTK/article/download/47449/465553521