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Efficient synthesis, molecular docking and biological evaluation of novel isatine linked spiroheterocycle through multi-component reaction

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Title Efficient synthesis, molecular docking and biological evaluation of novel isatine linked spiroheterocycle through multi-component reaction
 
Creator Gamit, Kumar G
Patel, Navin B
Chabhadiya, Bhadresh Kumar K
Jauhari, Smita
 
Subject N-Mannich base
Isatine
Gabbapentin-lactum
Antibacterial activity
Antifungal activity
 
Description 400-406
In this work, twelve compounds have been newly synthesized by one pot N-Mannich base multicomponent reaction. The
synthesized compounds have been characterized by using FT-IR, 1H and 13C NMR and mass spectrometry. The final
compounds have been evaluated for their in vitro antibacterial and antifungal activity using agar-well diffusion method. The
tested compounds show poor to good activity with inhibition zone value between 8 to 25 mm, when compared to reference
Ciprofloxacin and Flocanazole. Among them compounds 6b, 6c, 6d and 6g show most promoting activity against E.coli, B.
cereus, B. substilis, A. niger and R. nigricans.
 
Date 2024-04-16T08:54:48Z
2024-04-16T08:54:48Z
2024-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63773
https://doi.org/10.56042/ijc.v63i4.7109
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(04) [April 2024]