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Biologically active sulfonamides moiety: Synthesis, antimicrobial and antimalarial activity

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Field Value
 
Title Biologically active sulfonamides moiety: Synthesis, antimicrobial and antimalarial activity
 
Creator Meena, Lakshman R
 
Subject Immunological
Multi-drug resistance
Antimicrobial
Antifungal
Antimalarial
 
Description 367374
At present the incident of microbial diseases, especially in immunologically compromised patients is life-long and a
growing health challenge. The increasing incidences of drug resistance has become a major concern for physicians. To deal
with the problem of these microbial diseases, amalgamation therapy has gained much interest. A new series of sulfonamides
hybrids 3a-g have been synthesized by the reaction of 4-aminoacetophenone with benzensulfonyl chlorides. They have been
screened for their antimicrobial and antimalarial activity against four bacteria and against three fugal stains. Compounds 3d,
3e and 3c have excellent antibacterial activities with MIC values of 25, 50 and 62.5 μg/mL respectively. The derivatives 3a,
3d, 3e and 3f exhibited high anti-antimalarial activity with mean IC50 values of 0.70, 0.42, 0.74 and 0.82 μg/mL
respectively.
 
Date 2024-04-16T09:23:07Z
2024-04-16T09:23:07Z
2024-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63778
https://doi.org/10.56042/ijc.v63i4.6840
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(04) [April 2024]