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Lycopene enriched tomato extract exerts modulatory effects on hypoxia, angiogenesis and metastasis during N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in mice

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Title Lycopene enriched tomato extract exerts modulatory effects on hypoxia, angiogenesis and metastasis during N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in mice
 
Creator NA, Chugh
N, Bhatia
P, Gupta
A, Koul
 
Subject Chemoprevention
Hepatocellular carcinoma
Lycopene
Lycopersicon esculentum
 
Description 290-304
The onset and progression of hepatocellular carcinoma (HCC) is associated with several molecular and physiological
changes in the tumor microenvironment. This provides a rationale for studying these changes throughout hepatic
carcinogenesis and their possible modulation by putative anti-cancer agents. The present study was designed to look into
the effects of lycopene enriched tomato extract (LycT) on markers linked with hypoxia, angiogenesis and metastasis
at advanced stages of N-nitrosodiethylamine (NDEA) induced HCC in mice. Female balb/c mice were divided into
four groups: Control, NDEA, LycT and LycT+NDEA. LycT was able to inhibit tumor formation and retard the
development of histoarchitectural alterations which was consonance with the serum levels of alpha-feto protein.
HCC development was associated with aggravated expression of markers linked to hypoxia (HIF), angiogenesis (VEGF,
CD 31) and metastasis (MMP-2, MMP-9). LycT mediated inhibition in tumorigenesis was accompanied by decrease
in expression of these markers. 99mTc-mebrofenin assay revealed diminished hepatic function in NDEA group which
improved with LycT administration. These observations at late stages of HCC and those of the early stages reported
previously, convincingly demonstrate that LycT effectively mitigated hepatic cancer possibly by modulating hypoxia,
angiogenesis and metastasis.
 
Date 2024-04-18T05:29:53Z
2024-04-18T05:29:53Z
2024-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63783
https://doi.org/10.56042/ijbb.v61i5.968
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.61(05) [May 2024]