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Functional relationship of Interferon regulator factor-5, Interferon-γ, and Hypoxia-induced factor-1α with COVID-19 during Pregnancy

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Title Functional relationship of Interferon regulator factor-5, Interferon-γ, and Hypoxia-induced factor-1α with COVID-19 during Pregnancy
 
Creator Gokce, Sefik
Herkiloglu, Dilsad
Erdogan, Omer
Gumus, Erkan
Cevik, Ozge
Ahmad, Sarfraz
 
Subject COVID-19
HIF-1α
IFN-γ
IRF-5
Pregnancy
qRT-PCR
 
Description 259-268
Interferon-gamma (IFN-γ), interferon regulator factor-5 (IRF-5), and hypoxia-induced factor-1 alpha (HIF-1α) are
amongst the key immune regulators that function in Coronavirus Disease 2019 (COVID-19).In most cases level of these
markers significantly change in COVID-19 cases, especially in more severe cases. In addition, pregnancy itself shows more
different immunological processes. So, we aimed to investigate the levels of IFN-γ, IRF-5, and HIF-1α in cases who had
COVID-19 during their pregnancy. Thirty-three unvaccinated pregnant women with COVID-19, and 129 unvaccinated
healthy pregnant women (control) were included in the study. IFN-γ, IRF-5, and HIF-1α levels were investigated in blood
samples taken from pregnant women and newborns, and in tissue samples of placenta. Mean IFN-γ and IRF-5 levels in
pregnant women with COVID-19 were significantly lower, whereas mean HIF-1α levels were significantly higher than the
controls (P< 0.001, for each). In the receiver operating characteristic (ROC) analyses of maternal samples for determination
of post-COVID-19 infection; the cutoff value of 2.015 ng/mg protein for IRF-5 level had a sensitivity of 81.8% and a
specificity of 82.5% [area under the ROC curve (AUC): 0.161; P< 0.001; lower bound (LB): 0.08; upper bound (UB):
0.241; confidence interval (CI) 95%)], and the cutoff value of 225.63 pg/mg protein for IFN-γ level had a sensitivity of
81.8% and a specificity of 85.7% (AUC: 0.147; P< 0.001; LB:0.08; UB: 0.241; CI 95%). Our findings show that
COVID-19 has a significant effect on IFN-γ, IRF-5, and HIF-1α levels in pregnant women, and thus these levels can be used
as a reliable biomarker for the diagnosis of COVID-19 in pregnant women.
 
Date 2024-04-18T05:36:33Z
2024-04-18T05:36:33Z
2024-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63786
https://doi.org/10.56042/ijbb.v61i5.8212
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.61(05) [May 2024]