Record Details

Reversal of restraint stress caused dendritic atropy in rats by Nardostachys jatamansi

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Reversal of restraint stress caused dendritic atropy in rats by Nardostachys jatamansi
 
Creator Karkada, Gloria
Shruthi, S
Shenoy, K Bhasker
 
Subject Dendritic atropy
Hippocampus
Nardostachys jatamansi
Neuron
Stress
Wistar rats
 
Description 353-361
Hippocampus and prefrontal cortex of brain have distinct role in encoding and retrieval of memories. Uncontrollable
stress may influence the structural alterations of limbic brain regions and atropy of neurons mainly in the regions like the
prefrontal cortex and hippocampus. Nardostachys jatamansi (D. Don) DC (NJE) is a perennial herb and is known for its
anti-Parkinson’s, hepatoprotective, neuroprotective, hypotensive and anti-diabetic activities. Even though, it is an effective
therapeutic intervention for memory impairment but, its effect on the neurons of the hippocampus is not clear. In this
context, the effect of NJE on chronic restraint stress induced dendritic atropy in rats was studied. Male Wistar rats
underwent 21 days of restraint stress in a close fitting rodent restrainer. In combined treatment groups rats were treated with
alcoholic extract of NJE at dosage of 200 mg/kg bw for 21 days along with chronic restraint stress. The dendritic
morphology of neurons was studied in Golgi-impregnated sections. Stress produced dendritic atropy significantly increased
the dendritic branching and intersections in experimental rats. Interestingly, treatment of stressed rats with NJE extract
resulted in the reversal of stress induced the dendritic atrophy. These results demonstrate that atrophy of dendritic neurons
caused by chronic restraint stress may be responsible for learning and memory impairment. Co-treatment of rats with NJE
showed enhancement in the dendritic branching in the hippocampus. Furthermore, NJE treatment significantly increased
superoxide dismutase activity and total antioxidant capacity in frontal cortex, hippocampus and striatum regions of brain.
Thus, our findings suggest that NJE is a potential neuroprotector, which might be beneficial in the treatment of stress
induced memory impairment.
 
Date 2024-04-18T06:29:32Z
2024-04-18T06:29:32Z
2024-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63793
https://doi.org/10.56042/ijtk.v23i4.10328
 
Language en
 
Relation Int Cl.24: A61K 36/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(4) [April 2024]