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Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

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Title Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications
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Creator Bhavna Gupta,
Vijayendra Kumar,
Gaurav Kumar,
Abdullah Khan,
Najam Akhtar Shakil,
Ashish Dhawan,
Virinder S. Parmar,
Jayant Kumar
Arthur C. Watterson
 
Subject Nanocarriers, amphiphilic copolymers, encapsulation, drug delivery, bio-active, micelles and Novozyme-435
 
Description Not Available
Nano-particles with controllable particle size and shape are of great interest in biomedical applications (1). From the standpoint of drug carrier design with wide applicability to a variety of hydrophobic drugs, an effective strategy would be to prepare a simple copolymer having the property to form stable polymeric micelles which can entrap hydrophobic drugs in the core (2). In this study, we have attached saturated and unsaturated long chain acid chlorides to the copolymer of PEG and dimethyl-5-aminoisophthalate via an
amide linkage in order to make the copolymers amphiphilic. Further, bioactive compounds like β-carotene, which has considerable double bond unsaturation and curcumin, which has considerable aromatic unsaturation, were encapsulated in these amphiphilic copolymers which successfully demonstrated their drug loading ability.
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Date 2024-04-22T17:42:53Z
2024-04-22T17:42:53Z
2011-11-01
 
Type Research Paper
 
Identifier Bhavna Gupta, Vijayendra Kumar, Gaurav Kumar, Abdullah Khan, Najam A. Shakil, Ashish Dhawan, Virinder S. Parmar, Jayant Kumar & Arthur C. Watterson (2011): Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications, Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 48:12, 1009-1015
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http://krishi.icar.gov.in/jspui/handle/123456789/82296
 
Language English
 
Relation Not Available;
 
Publisher Taylor and Francis