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Phytochemical screening and GC-MS analysis of Skimmia laureola Decne. leaves from the Kumaon Region of Uttarakhand, India

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Title Phytochemical screening and GC-MS analysis of Skimmia laureola Decne. leaves from the Kumaon Region of Uttarakhand, India
 
Creator Darmwal, Jyoti
Joshi, Pushpa
Koshyari, Vandana
Rawat, Neelam
Kathuria, Shubham
 
Subject Coumarins
Dictamnine
GC-MS
Medicinal plant
Phytochemicals
Therapeutics
 
Description 122-134
Skimmia laureola (DC.) Decne. is one of the most important traditional medicinal plants in the Rutaceae family, found in
the Western and Eastern Himalayan regions. Whole plants are well-known for their ethnobotanical and medical uses.
Looking at its traditional medicinal uses, the present study aimed to determine the phytochemicals through preliminary
phytochemical screening and to profile the bioactive compounds in the different solvent extracts of S. laureola using the
GC-MS technique. The phytochemical analysis revealed the presence of alkaloids, carbohydrates, flavonoids, coumarins,
steroids and terpenoids in all three extracts. The GC-MS analysis identified various phytoconstituents with varying
concentrations and molecular masses in each extract. Methanol extract revealed 57 compounds, ethyl acetate extract showed
73 compounds and 53 compounds were obtained from n-hexane extract. The predominant compounds were dictamnine
(19.72%), methoxsalen (11.56%) in methanol extract, dictamnine (16.37%), cycloeucalenol acetate (15.27%) in ethyl
acetate extract and tetracontane (19.35%), cycloeucalenol acetate (16.16%) in n-hexane extract. Some constituents such as
Cycloeucalenol acetate and 13,27-Cycloursan-3-one identified as triterpenoid compounds were observed and had not been
previously reported. This suggests the potential of this plant as a cost-effective source of dictamnine and methoxsalen,
which are already known for their therapeutic properties. Further detailed investigations are needed to elucidate the
therapeutic effects of these phytochemical constituents.
 
Date 2024-04-26T09:23:37Z
2024-04-26T09:23:37Z
2024-04
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63811
https://doi.org/10.56042/ijnpr.v15i1.6952
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61K 36/75
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(1) [March 2024]