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Anticonvulsant activity of Rudraksha (Elaeocarpus angustifolius Blume) bark against picrotoxin-induced convulsions in rats

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Title Anticonvulsant activity of Rudraksha (Elaeocarpus angustifolius Blume) bark against picrotoxin-induced convulsions in rats
 
Creator Dumka, Himani
Ram, Veerma
Bisht, Lata
Negi, Anoop Singh
Kumar, Ankit
Semwal, Deepak Kumar
 
Subject Anti-epileptic activity
Diazepam
GABA
Neurological disorders
Picrotoxin
 
Description 104-112
Epilepsy is a neurological condition characterized by recurrent electrical activity in the brain's temporal lobe. It is a
chronic disorder marked by an imbalance between excitatory and inhibitory neurotransmitters, resulting in uncontrolled
excitability. Current antiepileptic drugs often have limited effectiveness and pose challenges in patient management.
Literature surveys indicate that various species of Elaeocarpus have demonstrated antimicrobial, antioxidant, antidiabetic,
antiasthmatic, antihypertensive, and antidepressant properties. Since Rudraksha (Elaeocarpus angustifolius Blume) is
traditionally used to treat epilepsy and other brain-related disorders, the present study aimed to validate this claim by
evaluating the anti-epileptic activity of the ethanolic bark extract of E. angustifolius on picrotoxin-induced convulsive rats.
The extract at doses of 200 and 400 mg/kg BW was administered to rats for 14 days, followed by a single dose of picrotoxin
(7.5 mg/kg i.p.) on the 14th day, with diazepam (12 mg/kg i.p.) used as a reference drug. Various oxidative parameters such
as γ-aminobutyric acid (GABA), lactoperoxidase (LPO), superoxide dismutase (SOD), glutathione (GSH), and nitrate were
estimated at the end of the treatment period. In the picrotoxin-induced convulsion model, treatment with ethanolic bark
extract at 400 mg/kg caused a significant (p
 
Date 2024-04-26T09:27:48Z
2024-04-26T09:27:48Z
2024-04
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63813
https://doi.org/10.56042/ijnpr.v15i1.1782
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61P 25/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(1) [March 2024]