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Unveiling the pharmacological potential of Murraya koenigii against diabetic nephropathy

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Title Unveiling the pharmacological potential of Murraya koenigii against diabetic nephropathy
 
Creator Singh, Randhir
Farooq, Shah Asma
Devi, Sushma
Aggarwal, Rohini
Rangra, Naresh Kumar
 
Subject Diabetic nephropathy
Hyperglycaemia
Murraya koenigii
Oxidative stress
Streptozotocin
 
Description 87-103
This study aimed to explore the efficacy of various extracts derived from Murraya koenigii (L.) in managing diabetic
nephropathy (DN). DN was induced via intraperitoneal administration of streptozotocin (65 mg/kg), following a 15-minute
pre-treatment with NAD (230 mg/kg), to develop diabetes. Evaluation of DN involved monitoring level of fasting blood
glucose, glycated haemoglobin, serum insulin, albuminuria, serum urea, uric acid, creatinine, BUN, and alterations in lipid
profile (TC, TG, LDL, and HDL). The oral administration of hydroalcoholic extract derived from Murraya koenigii to
diabetic rats showed a notable improvement in renal dysfunction, as demonstrated by a marked decrease in inflammatory
markers. Moreover, the treated groups experienced significant increase in body weight and notable reductions in
fasting blood glucose and glycated haemoglobin levels. The administration of the extracts also effectively alleviated
hyperglycemia-induced oxidative stress, evidenced by a noteworthy rise in superoxide dismutase (SOD) and reduced
glutathione (GSH) levels, coupled with a considerable decrease in malondialdehyde (TBARS) levels. Additionally, the
treatment led to the reversal of histopathological abnormalities observed in the kidneys, pancreas, and liver of diabetic rats.
These findings indicate that treatment with M. koenigii extracts alleviated DN.
 
Date 2024-04-26T09:29:52Z
2024-04-26T09:29:52Z
2024-04
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63814
https://doi.org/10.56042/ijnpr.v15i1.5247
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61P
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(1) [March 2024]