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Evaluation of the antioxidant activity of novel south Indian plant Commelina forskaolii and its prospective anticancer activity in Hep G2 cells

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Title Evaluation of the antioxidant activity of novel south Indian plant Commelina forskaolii and its prospective anticancer activity in Hep G2 cells
 
Creator Raju, Manikandan Vani
Sekar, Sasikala
Chandrasekaran, Meenakshi Kaniyur
Rajendran, Meenakshi Sundari
Ahalliya, Rathi Muthaiyan
 
Subject Anticancer
Antioxidant
Commelina forskaolii
Oxidative stress
Phytochemicals
Sequential extraction
 
Description 65-72
Oxidative stress plays a part in the progression of cancer and various types of diseases by damaging the DNA. Generally,
plants have high antioxidant potency so that they can reduce oxidative stress. Plants are found to be effective in treating
various types of cancers because of their antioxidant property. Commelina forskaolii was used in the primitive ages to treat
various diseases. This study evaluated the antioxidant and cytotoxic potential of the novel medicinal plant C. forskaolii
followed by qualitative and quantitative phytochemical analysis. DPPH, ABTS and hydroxyl radical scavenging activity
were used to determine the antioxidant potential. The HepG2 cell line was used to study anticancer activity because it is a
widely used cell line to study hepatotoxicity and hepatocellular carcinoma. The plant showed favourable antioxidant activity
by scavenging various radicals such as DPPH, ABTS and hydroxyl radicals due to the presence of phytochemicals such as
alkaloids, flavonoids, glycosides, tannins and terpenoids. Compared to the other plant extracts, the aqueous extract was
found to be more potent in scavenging free radicals. The plant showed cytotoxicity against the HepG2 cell lines. The
medicinal plant C. forskaolii contains a variety of phytochemicals and has high antioxidant potential. The plant has a
capacity to inhibit the growth of liver cancer cells.
 
Date 2024-04-26T09:34:59Z
2024-04-26T09:34:59Z
2024-04
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63816
https://doi.org/10.56042/ijnpr.v15i1.4468
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61P, A61P 35/00, A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(1) [March 2024]