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Effects of two types of exercises on MCT1 and GLUT4 expression in visceral white adipose tissue in type I diabetic rats

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Title Effects of two types of exercises on MCT1 and GLUT4 expression in visceral white adipose tissue in type I diabetic rats
 
Creator Mirtajaddini-Goki, Maryamossadat
Abbaspour, Mehdi
Kordestani, Zeinab
Yeganeh-Hajahmadi, Mahboobeh
 
Subject Diabetes mellitus
Endurance training
Exercise
Glucose transporter
Lactate transporter
 
Description 366-371
White adipose tissue plays an important role in controlling the body's metabolism. In type I diabetes mellitus (T1DM),
the function of this tissue is severely impaired. The beneficial effects of exercise have been shown in this condition. In this
study, we investigated how exercise can benefit on T1DM. Thus, we studied the effects of moderate-intensity endurance
training (MIET) and high-intensity interval training (HIIT) on MCT1 and GLUT4 levels in visceral white adipose tissue
(vWAT) of T1DM rats. Twenty-eight male rats were divided into four groups: control, T1DM, T1DM+HIIT, and
T1DM+MIET. The expression of MCT1 and GLUT4 mRNAs was evaluated in vWAT after 12 weeks of training. The
mRNA levels of MCT1 and GLUT4 decreased in T1DM but increased in both the exercised groups. The effects of HITT
and MIET on these genes were similar. MIET and HIIT led to increasing levels of MCT1 and GLUT4 mRNA in white
adipose tissue. This can probably improve adipose tissue health and ultimately glucose homeostasis in T1DM.
 
Date 2024-04-29T04:41:44Z
2024-04-29T04:41:44Z
2024-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63822
https://doi.org/10.56042/ijeb.v62i05.1477
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(05) [May 2024]