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Antiepileptic effects of Allium schoenoprasum L. in the acute epilepsy model in rats

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Title Antiepileptic effects of Allium schoenoprasum L. in the acute epilepsy model in rats
 
Creator Zaqzouq, Dana
Him, Aydin
Guneser, Ramazan
Turker, Arzu
 
Subject Antiepileptic drugs
Chives
Herbal
Seizure
Traditional medicine
 
Description 359-365
Epilepsy is a chronic clinical disorder and does not have a rational treatment, which basically aims to prevent seizure
activity. Therefore, developing new treatment strategies that can intervene in epileptogenesis will make important
contribution to epilepsy treatment. In order to find new compounds and develop new treatment strategies, here, we explored
the potential antiepileptic effects of Allium schoenoprasum L. commonly known as chives. Two different epilepsy models
were used to study the potential antiepileptic effects of A. schoenoprasum L. The first epilepsy model was induced by
intracortical injection of 500 IU penicillin. The second epilepsy model was induced by injecting pentylenetetrazol (PTZ) at
the dose of 60 mg intraperitoneally (i.p.). In the penicillin model, the animals were given A. schoenoprasum L. extract
(200 or 400 mg/kg i.p.) after penicillin was applied and electrocortical activity was recorded for 120 min. In the PTZ model,
the animals were given A. schoenoprasum L. extract at doses of 200 or 400 mg/kg orally for 7 days, after which the PTZ
was applied, and tonic-clonic seizures were video recorded. A. schoenoprasum L. did not significantly change either the
spike frequency or amplitude in the penicillin epilepsy model. Although it did not change the seizure score in the PTZ
epilepsy model it reduced the death rate and significantly decreased the tonic-clonic seizure duration. The result suggests
that A. schoenoprasum L. may have antiepileptic effects when applied chronically.
 
Date 2024-04-29T04:44:03Z
2024-04-29T04:44:03Z
2024-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63823
https://doi.org/10.56042/ijeb.v62i05.2825
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(05) [May 2024]