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Effect of chrysin on oxidative stress, biochemical, and inflammatory alterations in Wistar albino rats exposed to cypermethrin

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Title Effect of chrysin on oxidative stress, biochemical, and inflammatory alterations in Wistar albino rats exposed to cypermethrin
 
Creator Tekeli, Muhammet Yasin
Koc, Feride
Calimli, Sinem
Aslan, Coşkun
 
Subject Aspartate aminotransferase
Glutathione
Interleukin
Malondialdehyde
Pesticide toxicity
Tumor necrosis factor
 
Description 349-358
Cypermethrin is a broad-spectrum pesticide commonly used in agricultural, veterinary and household applications.
Cypermethrin, being a neurotoxic agent and due to its hydrophobic structure, may cause tissue and organ damage by stimulating
oxidation in cells and increasing reactive oxygen species. It has a detrimental effect on the immune system and promote
inflammation by producing cytokines. The harmful effects of cypermethrin may be alleviated by the intracellular defense system
that reduces ROS. Chrysin, a flavonoid, commonly found in vegetables, propolis, honey, fruits and mushrooms, is known to
possess antioxidant, antiviral, antidiabetic and anticarcinogenic properties. It provides protection against disease and toxicity
through various mechanisms. In this study, we investigated the protective effects of chrysin against oxidative damage in rats
exposed to cypermethrin. There is no research on the response of chrysin to the toxicity of cypermethrin in mammals and whether it
can be used among treatment options or as a supplement to treatment. A total of thirty 6-8 week old male Wistar albino rats, each
weighing 190-240 g, were used and divided into six equal groups, randomly. The groups were formed as control (Gr.I),
cypermethrin (25 mg/kg body wt.) (Gr.II), cypermethrin (25 mg/kg body wt.) plus chrysin (50 and 100 mg/kg body wt.) (Gr. III &
IV, respectively); and chrysin (50 and 100 mg/kg body wt.) (gr. V & VI, respectively). The indicated doses were given orally for
10 days. Cypermethrin and chrysin were given to the animals alone and together within the specified groups. In blood/tissue
samples (brain, heart, kidney, liver, lung and testis), lipid peroxidation/oxidative stress parameters (MDA, NO, CAT, SOD, GSH
and GSH-Px) and serum biochemicals (AST and ALT) and inflammatory parameters (TNF-α, IL-1β and IL-6) were evaluated.
When a general evaluation is made, compared to the control group, cypermethrin considerably increased the levels of TNF-α,
IL-1β, IL-6, ALT, AST in serum and MDA and NO in tissues/plasma, while significantly decreasing the levels/activities of SOD,
CAT, GSH and GSH-Px in tissues/erythrocytes (P
 
Date 2024-04-29T04:46:16Z
2024-04-29T04:46:16Z
2024-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63824
https://doi.org/10.56042/ijeb.v62i05.2887
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(05) [May 2024]