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Effect of Nigella sativa L. extract and thymoquinone on the genes responsible for cell proliferation, migration and NK cell cytotoxicity in breast cancer

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Title Effect of Nigella sativa L. extract and thymoquinone on the genes responsible for cell proliferation, migration and NK cell cytotoxicity in breast cancer
 
Creator Korak, Tuğcan
Emrence, Zeliha
Ekmekci, Sema Sırma
Abacı, Neslihan
Ergül, Emel
 
Subject Anticancer
Black cumin
Kalonji
 
Description 317-325
The black cumin, Nigella sativa L. is known to be effective against various diseases including cancer. Thymoquinone
(TQ), active ingredient of N. sativa extracts, can inhibit proliferation metastasis and regulating immune system in different
cancers as with breast cancer (BC). The mechanisms of action behind TQ are not clearly understood yet. The purpose of the
current study is to investigate the effects of TQ, water (WE) and alcohol extracts (AE) of N. sativa on BC cells by focusing
attention on the following genes; CDK4, MYC, NF-κB1, VEGFA, FGF1, N-cadherin, ULBP1, ULBP2 and CD155.
Conventional protocols were performed in order to obtain extracts. Cell viability was measured by RTCA and MTT assay,
and gene expressions were analyzed by qRT-PCR. Association was significant for CDK4 (P =0.07), MYC (P
 
Date 2024-04-29T04:57:13Z
2024-04-29T04:57:13Z
2024-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63828
https://doi.org/10.56042/ijeb.v62i05.3890
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(05) [May 2024]