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Study of Protective Effect of Curcumin and Quercetin Against Subacute Toxicity of Fipronil in Rats

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Title Study of Protective Effect of Curcumin and Quercetin Against Subacute Toxicity of Fipronil in Rats
 
Creator Yadav, Durgesh
Dewangan, Gayatri
Rajput, Neetu
Shrivastava, Nidhi
 
Subject Fipronil
Flavonoid
Protective effect
Rats
Turmeric
 
Description 525-530
Fipronil is belonged to phenyl pyrazole class of pesticides, used in the veterinary, public health, and agricultural fields to
control a variety of pests. Numerous researchers have looked into the possibility that long-term exposure to fipronil causes
liver and renal disease. It has been shown that curcumin and quercetin provide protection against the toxicity caused by
numerous pesticides. The purpose of our study was to investigate the possible preventive role of quercetin and curcumin in
hepatic and renal damage caused by fipronil. The rats were divided into five groups, with six rats in each group. Group I was
not given any medication and treated as control, while rats of treatment groups were orally administered with the fipronil at
dose 10 mg∙kg−1b.wt to group I, fipronil and curcumin (10 mg∙kg−1b.wt +100 mg∙kg−1b.wt) to group III, fipronil
and quercetin (10 mg∙kg−1b.wt +100 mg∙kg−1b.wt ) to group IV and combination of fipronil, curcumin and quercetin
(10 mg∙kg−1b.wt +100 mg∙kg−1b.wt +100 mg∙kg−1b.wt ) to group V. After exposure, biochemical markers were measured on
days 0, 14, and 28th day of study period. Body weight of rats significantly decreased throughout the course of 28 days of
exposure to fipronil. Hepatic and renal damage caused by fipronil was indicated by significant increase in the serum levels
of AST, ALT, ALP, LDH, BUN, and creatinine, which were recorded at different intervals during the study period.
Nevertheless, the negative effects of fipronil were significantly reduced by supplementing with curcumin and quercetin,
both separately and together. This was demonstrated by a considerable drop in the raised level of serum biochemical
markers. The current study concludes that quercetin and curcumin may function as effective protective agents against
toxicity generated by fipronil.
 
Date 2024-05-06T11:11:44Z
2024-05-06T11:11:44Z
2024-05
 
Type Article
 
Identifier 0022-4456 (Print); 0975-1084 (Online)
http://nopr.niscpr.res.in/handle/123456789/63854
https://doi.org/10.56042/jsir.v83i5.3251
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source JSIR Vol.83(5) [May 2024]