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Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens

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Title Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens
 
Creator Gnanadesigan, M
Dhass, A
Nandagopalan, V
Rajagopalan, V
Saravanan, V
 
Subject Bruguiera cylindrica
Cytotoxicity
MBC
MIC
Rhizophora mucronata
SEM
 
Description 381-389
This research aimed to determine the bactericidal and cytotoxic properties of two mangrove plants commonly used in
traditional medicine: Bruguiera cylindrica (leaf) and Rhizophora mucronata (stilt root). The selected plant parts were subjected
to solvent polarity-based extraction. Of the solvent extracts, the acetone, ethyl acetate leaf extract of B. cylindrica and acetone
stilt root extract of R. mucronata were chosen for further study as they exhibited minimum inhibitory and bactericidal
concentrations between 0.5 and 1.0 mg.ml-1 against MTCC 435, Vibrio cholerae and Escherichia coli. The well and disk
diffusion analysis of these mangrove extracts showed inhibition zone between 6 – 16 mm diameter for the bacterial pathogens.
Similarly, the mangrove extracts displayed > 98 % reduction of viable counts for MTCC 435, E. coli and V. cholerae at
different time intervals between 8 – 16 h. Electron microscope analyses of the bacterial cells treated with mangrove extracts
confirmed the bactericidal properties by cellular aggregation and leakage. Further, the cytotoxicity evaluation of mangrove
extracts with Henrietta Lacks cell lines did not show any viability interference up to 200 μg.ml-1, indicating their non-toxicity to
human cells and biocompatibility for drug development. The research findings suggest that the acetone, ethyl acetate leaf
extract of B. cylindrica and the acetone stilt root extract of R. mucronata could be used as a bactericidal resource against
V. cholerae, MTCC 435 and E. coli.
 
Date 2024-05-16T06:47:10Z
2024-05-16T06:47:10Z
2024-05
 
Type Article
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/63909
https://doi.org/10.56042/ijms.v52i08.11021
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJMS Vol.52(08) [August 2023]