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New polymorphic forms of Lenvatinib mesylate and process for their preparation

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Title New polymorphic forms of Lenvatinib mesylate and process for their preparation
 
Creator Trivedi, Madhavkumar
Chavda, Rajendra
Kathrotiya, Harshad
Vora, Pratik
Dubal, Gaurang G
 
Subject Lenvatinib mesylate
Lenvatinib
Powder X-ray diffraction
Thermal analysis
Differential scanning calorimetry
 
Description 464-472
This work involves creating and characterizing stable polymorphic forms of Lenvatinib mesylate while ensuring
pharmaceutical purity. The process is optimized and uses various analytical techniques such as thermal analysis, powder
X-ray diffraction, and differential scanning calorimetry to examine these forms. Using these techniques, these forms can be
synthesized on a commercial scale with high efficiency and purity, including two new polymorphs (form 1 and 2) that are
highly pure. These findings provide valuable insights into preparing and characterizing stable Lenvatinib mesylate forms,
beneficial for developing new pharmaceutical products in the industry. The recognition of a newly discovered, stable
polymorph of the anti-cancer molecule marks a crucial milestone in the domain of drug development. This finding not only
enhances our comprehension of the molecular characteristics of the compound but also carries the potential for revolutionary
effects on cancer therapy in terms of molecular stability.
 
Date 2024-05-20T04:47:31Z
2024-05-20T04:47:31Z
2024-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63920
https://doi.org/10.56042/ijc.v63i5.8497
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(05) [May 2024]