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In vitro and in silico studies of methanol extract of Bridelia stipularis on S. aureus and E. coli

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Title In vitro and in silico studies of methanol extract of Bridelia stipularis on S. aureus and E. coli
 
Creator A, Sini
K, Bindu T
Raphael, Vinod P
S, Shaju K
 
Subject Bridelia stipularis
Transferase
Oxidoreductase
Phosphotransferase
Docking
 
Description 437-443
Bacterial resistance to contemporary antibiotics is an emerging problem in allopathy. The pursuit of a novel therapeutic
agent with superior activity to conventional antibacterial agents has piqued the interest of pharmaceutical scientists in recent
decades. It has been established by several scientists that plant extracts are the source of many valuable phytochemicals that
may have a variety of medicinal activities. Some of the compounds present in Bridelia stipularis (BS) are reported to have
anti-cancer and anti-microbial activities. In the present work, we examined the phytochemicals present in the methanol
extract of BS using GC-MS analysis. The extract was screened for anti-bacterial activity against S. aureus and E. coli in
DMSO using the well-cut method. The extract's activity was comparable to that of standard antibiotics such as
erythromycin, streptomycin, cefotaxime and cloxacillin. In silico investigations of the phytochemicals that have the highest
proportion in the extract were conducted with the structural proteins of S. aureus and E. coli. Among the identified
compounds, steroidal and sulphonyl hydrazone molecules showed high binding affinity on the enzymes of E. coli and
S. aureus. Binding analysis of highly stable receptor-ligand complexes were discussed in the article.
 
Date 2024-05-20T05:04:45Z
2024-05-20T05:04:45Z
2024-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63924
https://doi.org/10.56042/ijc.v63i5.6713
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(05) [May 2024]