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Dynamic protective potential of Couroupita guianensis Aubl. against reactive free radicals: An approach of simulated in vitro model

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Title Dynamic protective potential of Couroupita guianensis Aubl. against reactive free radicals: An approach of simulated in vitro model
 
Creator D, Kavitha
M, Madhumitha
R, Ramya
C, Kumarappan
 
Subject Antioxidant
Couroupita guianensis Aubl
Free radicals
Goat liver slices
In vitro model
 
Description 441-451
Oxygen is a prominent element in the well-being of humans, but also responsible for causing tissue damage. The oxygen
molecule gets reduced to form a highly reactive oxygen species due to various metabolic events happening in the host. The
generated free radicals could react with other biomolecules like protein, lipid, carbohydrate and nucleic acid to impart severe
diseases and disorders. Antioxidants could effectively block the oxidation process by neutralizing the produced free radicals.
Hence, the present study aims to validate the potent antioxidant activities of Couroupita guianensis Aubl. using goat
liver slices that could serve as an in vivo simulated in vitro model. The methanolic extract and the alkaloid fraction of
both leaves and flowers of C. guianensis Aubl. were prepared and their enzymatic and non-enzymatic antioxidant
activities were evaluated. Hydrogen peroxide was used as a standard free radical throughout the experiments in all the
treatment groups. The results have envisaged that the plant has enormous antioxidant activities in oxidatively stressed
goat liver slices to combat various oxidative stress-related diseases and disorders. Conclusively, the in vitro model
system to explore the antioxidant profiles will eventually mitigate the sacrifice of animals by exactly mimicking the in
vivo conditions for research endeavors.
 
Date 2024-05-22T09:22:56Z
2024-05-22T09:22:56Z
2024-05
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63950
https://doi.org/10.56042/ijtk.v23i5.11035
 
Language en
 
Relation Int Cl.24: A61K 36/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(5) [May 2024]