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Combined hepatoprotective potentials of medicinal plants on CCl4-induced hepatotoxic Wistar rats

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Title Combined hepatoprotective potentials of medicinal plants on CCl4-induced hepatotoxic Wistar rats
 
Creator Akhter, Samina
Jahan, Iffat
Roy, Dipankar Chandra
Shah, Ahad
Islam, Dipa
Lipy, Evena Pervin
Lyzu, Chadni
Hakim, Mahmuda
Rahman, Md Tazinur
 
Subject Antioxidant
CCl4
Hepatoprotection
Liver damage
 
Description 433-440
Asparagus racemosus Willd., Cajanus cajan (L.) Millsp., Cassia fistula L., and Carissa spinarum L. (ACCC) are used in ethnomedicine for treating a variety of diseases, including liver disease. The present study investigated the combined antioxidative and hepatoprotective roles of an aqueous methanol extract of ACCC (AMACCC) on CCl4-induced hepatic damage in the rat model. Thirty male Wistar Albino rats were divided uniformly into five groups. Group I (control) received only the vehicle DMSO (0.5 mL/kg b.w.) and was fed a normal diet for 28 days. Carbon tetrachloride (0.5 mL/kg b.w., 20% CCl4/olive oil) was used to intoxicate groups II-V. Rats in Group II remained untreated, while groups III, IV, and V were given 50 mg/kg b.w. of sylimarin, 100 mg/kg b.w., and 200 mg/kg b.w. of AMACCC, respectively, for 28 days. Investigations were conducted to evaluate the combined action of AMACCC on liver marker enzymes along with histopathological changes of hepatic tissue before and after treatment. In vitro antioxidative activity of AMACCC was also observed. There were significant increases (p
 
Date 2024-05-22T09:25:23Z
2024-05-22T09:25:23Z
2024-05
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63951
https://doi.org/10.56042/ijtk.v23i5.11045
 
Language en
 
Relation Int Cl.24: A61K 36/00, A61P 1/16
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(5) [May 2024]