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Effect of Naga Parpam, a metallic drug of Siddha medicine, on lipid peroxidation, antioxidant enzymes and tissues of liver in Wistar rats

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Title Effect of Naga Parpam, a metallic drug of Siddha medicine, on lipid peroxidation, antioxidant enzymes and tissues of liver in Wistar rats
 
Creator Ilango, Balakrishnan
Kumar, Krishnamurthi Vinoth
Ezhilarasan, Devaraj
Sukumar, Ethirajan
 
Subject Antioxidant enzymes
Lipid peroxidation
Liver tissues
Naga Parpam
Wistar rats
 
Description 420-422
Naga Parpam (NP), a zinc containing drug is prescribed in
Siddha medicine to treat piles, fistula, dysentery, diarrhoea and
tuberculosis. In this investigation, NP’s effect on lipid
peroxidation, antioxidant enzymes and tissues of liver in Wistar
rats has been studied. The drug was administered orally in doses
of 5, 10 and 20 mg/kg body weight for 28 days to the
experimental animals. On day 29, they were sacrificed and the
liver was removed. From the liver homogenate, lipid peroxidation
(LPO) and the activities of antioxidant enzymes (catalase,
superoxide dismutase and glutathione peroxidase) were analyzed.
Dose dependent decrease in LPO and increase in the above
enzymes revealed its potential antioxidant activity. There were no
significant changes in the liver tissue architecture in histology that
further confirmed the pro-active role of NP in treating diseases.
 
Date 2024-05-22T09:30:48Z
2024-05-22T09:30:48Z
2024-05
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63953
https://doi.org/10.56042/ijtk.v23i5.11046
 
Language en
 
Relation Int Cl.24: A61K 31/315
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(5) [May 2024]