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<p><strong>Combined hepatoprotective potentials of medicinal plants on CCl<sub>4</sub>-induced hepatotoxic Wistar rats</strong></p><p> </p>

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Title Statement <p><strong>Combined hepatoprotective potentials of medicinal plants on CCl<sub>4</sub>-induced hepatotoxic Wistar rats</strong></p><p> </p>
 
Added Entry - Uncontrolled Name Akhter, Samina ; Bangladesh Council of Scientific and Industrial Research
Jahan, Iffat ; Bangladesh Council of Scientific and Industrial Research
Roy, Dipankar Chandra; Bangladesh Council of Scientific and Industrial Research
Shah, Ahad ; Shahjalal University of Science and Technology
Islam, Dipa ; Bangladesh Council of Scientific and Industrial Research
Lipy, Evena Pervin; Bangladesh Council of Scientific and Industrial Research
Lyzu, Chadni ; Bangladesh Council of Scientific and Industrial Research
Hakim, Mahmuda ; Bangladesh Council of Scientific and Industrial Research
Rahman, Md Tazinur; Bangladesh Council of Scientific and Industrial Research
Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh (grant number 39.02.0000.11.014.007.2017/848).
 
Uncontrolled Index Term Antioxidant, CCl4, Hepatoprotection, Liver damage.
 
Summary, etc. <p><em>Asparagus racemosus</em> <em>Willd.</em>, <em>Cajanus cajan</em> <em>(L.) Millsp.,</em> <em>Cassia fistula</em> <em>L.</em>,<em> </em>and<em> </em><em>Carissa spinarum</em> L. (ACCC<em>)</em><em> </em>are used in ethnomedicine for treating a variety of diseases, including liver disease. The present study investigated the combined antioxidative and hepatoprotective roles of an aqueous methanol extract of ACCC (AMACCC) on CCl<sub>4</sub>-induced hepatic damage in the rat model. Thirty male Wistar Albino rats were divided uniformly into five groups. Group I (control) received only the vehicle DMSO (0.5 mL/kg b.w.) and was fed a normal diet for 28 days. Carbon tetrachloride (0.5 mL/kg b.w., 20% CCl<sub>4</sub>/olive oil) was used to intoxicate groups II–V. Rats in Group II remained untreated, while groups III, IV, and V were given 50 mg/kg b.w. of sylimarin, 100 mg/kg b.w., and 200 mg/kg b.w. of AMACCC, respectively, for 28 days. Investigations were conducted to evaluate the combined action of AMACCC on liver marker enzymes along with histopathological changes of hepatic tissue before and after treatment. In vitro antioxidative activity of AMACCC was also observed. There were significant increases (p &lt; 0.001) in serum hepatic enzyme markers (ALT, AST, and ALP) activities in rats intoxicated with CCl<sub>4 </sub>when<sub> </sub>compared to the normal group, but administration of AMACCC extract at doses of 100 mg/kg and 200 mg/kg body weight and standard sylimarin drug attenuated (p &lt; 0.01) the toxic effects of CCl<sub>4. </sub>The treated liver was shown to be in repair histopathologically. The combination of the four plant extracts has a strong hepatoprotective effect, indicating that more research is needed.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-05-27 15:19:02
 
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http://op.niscair.res.in/index.php/IJTK/article/view/61905
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 5 (2024): Indian Journal of Traditional Knowledge
 
Language Note en