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Evaluation of <em>in vitro </em>immunomodulatory and antimicrobial activity with safety study of granules of <em>Naque Nazla</em>

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Title Statement Evaluation of <em>in vitro </em>immunomodulatory and antimicrobial activity with safety study of granules of <em>Naque Nazla</em>
 
Added Entry - Uncontrolled Name Nafees Ahmad, Khan Nusrat Bano ; Deptartment of Ilmul Advia, National Institute of Unani medicine (NIUM) Bangalore 560 091, India
Wadud, Abdul ; Deptartment of Ilmul Advia, National Institute of Unani medicine (NIUM) Bangalore 560 091, India
Hamiduddin, Hamiduddin ; Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani medicine (NIUM) Bangalore 560 091, India
Zaigham, Mohammad ; Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani medicine (NIUM) Bangalore 560 091, India
Jabeen, Uzma ; Department of Biosciences, Jamia Millia Islamia, New Delhi 110 025, India
 
Uncontrolled Index Term Antimicrobial activity, Granules, Immunomodulation, Naque Nazla, Unani medicine
 
Summary, etc. <p>Common cold and flu are frequently occurring in humans, if not managed, can cause secondary infections and other complications. It may be minimized by boosting immunity, which can be done by Unani Medicine. Objective of this study is to evaluate <em>in vitro</em> immunomodulatory and antimicrobial activity and safety of granules of <em>Naque Nazla,</em> a famous Unani infusion / decoction. <em>Naque Nazla </em>granules (NNG) were tested for its immunomodulatory activity by lymphocyte proliferation assay and macrophage phagocytosis and antimicrobial activity by well diffusion method. LC-MS and GC-MS was done for standardization. Acute toxicity study was carried as per OECD guidelines 423, to evaluate safety of granules. THP-1 cells study displayed EC50 value of 997.6 µg/mL with a proliferation of 53.95% at 1280 µg/mL. Phagocytosis assay displayed 67.85% phagocytosis at 1280 µg/mL, antimicrobial activity was tested against common respiratory tract bacteria which showed susceptibility against <em>Klebsiella pneumoniae</em>, <em>Salmonella</em> spp., <em>Staphylococcus aureus</em>, and <em>Streptococcus pyogenes. </em>LC-MS and GC-MS fingerprinting data was set in and revealed the presence of many phytochemicals. Acute toxicity study displayed the drug safe up to 2000 mg/kg. NNG displayed immunomodulatory and antimicrobial activity in</p><p><em>in vitro</em> study and was also found safe.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-05-27 15:19:02
 
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http://op.niscair.res.in/index.php/IJTK/article/view/72543
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 5 (2024): Indian Journal of Traditional Knowledge
 
Language Note en