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Post-Vaccination Sero-Monitoring of Peste des Petits Ruminants in Sheep and Goats in Karnataka: Progress Towards PPR Eradication in India.

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Title Post-Vaccination Sero-Monitoring of Peste des Petits Ruminants in Sheep and Goats in Karnataka: Progress Towards PPR Eradication in India.
Not Available
 
Creator Balamurugan V
Ojha, R.
Kumar, K.V.
Asha, A.
Ashraf, S.
Dsouza, A.H.
Pal, A.
Bokade, P.P.
Harshitha, S.K.
Deshpande, R
Mahadevappa Swathi
Kuralayanapalya Puttahonnappa Suresh
GurrappaNaidu Govindaraj
Subramanya Prasad Hasnadka
Shanmugam ChandraSekar
Divakar Hemadri
Anirban Guha
Njeumi Felix
Satya Parida
Baldev Raj Gulati
 
Subject PPR eradication
GCES guidelines
mass vaccination
post-vaccination sero-monitoring
vaccine efficacy
epidemiological unit
Karnataka state; India
 
Description Not Available
Abstract
Peste des petits ruminants (PPR) presents economic challenges in enzootic countries impacting small ruminant productivity. The state of Karnataka, India, implemented a mass vaccination campaign in alignment with the PPR-Global Eradication Programme (GEP) and the National Strategic Plan for PPR eradication. This study was conducted from January to March 2023 to assess seroconversion in post-vaccinated goats and sheep at the epidemiological unit (epi-unit) level, aligning with the World Organisation for Animal Health (WOAH) and the Food and Agriculture Organization (FAO) guidelines in the PPR Global Control and Eradication Strategy (GCES). Before vaccination, 3466 random serum samples were collected from small ruminants of three age groups (6–12 months, 1–2 years, and >2 years) across 116 epi-units, spanning 82 taluks in 28 districts. Post-vaccination sero-monitoring included 1102 serum samples collected from small ruminants of the 6–12-month age group only, across 111 epi-units covering 64 taluks in 23 districts. The PPRV antibody status was determined using an indigenous hemagglutinin (H) protein monoclonal antibody-based competitive ELISA kit. Pre-vaccination, the PPR seropositivity rates were 55%, 62%, and 66% in the age groups of 6–12 months, 1–2 years, and >2 years, respectively, with a 61% PPRV antibody prevalence across all the age groups. Notably, 41% of the epi-units exhibited antibody prevalence rates of ≥70%, indicating a substantial population immunity, possibly attributed to the previous vaccination program in the state since 2011. In contrast, only 17% of the epi-units had below 30% seroprevalence rates, emphasizing the need for intensified vaccination. Statistical analysis of the data revealed significant correlations (p < 0.05) between the presence of PPRV antibodies and host factors such as species, breed, and sex. Post-vaccination seroprevalence in the 6–12 months age group was found to be 73.4%, indicating the use of an efficacious vaccine. On the evaluation of vaccination immunity in the 6–12 months age group, it was revealed that over 69% of the epi-units achieved a response surpassing ≥70%, indicating a significant improvement from 42% of the epi-units in pre-vaccination. For active PPR eradication, a mass vaccination campaign (>95% coverage) targeting small ruminant populations aged >4 months is advocated, aiming to achieve the desired herd immunity of >80%. This study offers crucial insights into PPR baseline seroprevalence/immunity status and vaccine efficacy, guiding national strategies towards a PPR-free India and further supporting the global eradication initiative.
he research was conducted at ICAR-NIVEDI through the PPR-EP project (ANSCNIVEDICOL2022800133) funded by the DAHD, Government of India, under the Critical Animal Disease Control Programme (CADCP) of Livestock Health & Disease Control (LH&DCP) scheme No. K-11053(5313)/21/2019-LH (E-14082).
 
Date 2024-04-23T09:14:41Z
2024-04-23T09:14:41Z
2024-02-22
 
Type Article
Journal
Research Paper
 
Identifier Not AvailaBalamurugan, V.; Ojha, R.; Kumar, K.V.; Asha, A.; Ashraf, S.; Dsouza, A.H.; Pal, A.; Bokade, P.P.; Harshitha, S.K.; Deshpande, R.; et al. Post-Vaccination Sero-Monitoring of Peste des Petits Ruminants in Sheep and Goats in Karnataka: Progress towards PPR Eradication in India. Viruses 2024, 16, 333. https://doi.org/10.3390/v16030333ble
1999-4915
http://krishi.icar.gov.in/jspui/handle/123456789/82298
 
Language English
 
Relation Not Available;
 
Publisher Viruses